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Drug Targeting by Solid Lipid Nanoparticles for Dermal Use
Interestingly, PC incorporation into nanoparticles appeared to induce a localizing effect in the epidermal layer which was pronounced at 6 h and declined later, and may increase the benefit/risk ratio of topical therapy.
Albumin effects on drug absorption and metabolism in reconstructed epidermis and excised pig skin.
Surprisingly, the addition of BSA to the acceptor medium slightly reduced the steroid permeation, especially when formulations of poor PC uptake were tested, and the metabolite pattern changed as compared to PC metabolites to be found in albumin-free acceptormedium.