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Isolation and Characterization of Mesenchymal Stromal Cells From Human Degenerated Nucleus Pulposus: Comparison With Bone Marrow Mesenchymal Stromal Cells From the Same Subjects
TLDR
Findings suggest that intervertebral disc degeneration may be treated by cell therapy (MSC from BM) and by stimulating endogenous MSC from NP, which is quite similar to mesenchymal stem cells from BM, with the exception of their adipogenic differentiation ability. Expand
Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.
TLDR
Individuals homozygous for the T allele had an increased likelihood of developing ONJ, and SNP rs1934951 was significantly associated with a higher risk of ONJ development even after Bonferroni correction. Expand
Long FLT3 internal tandem duplications and reduced PML-RARα expression at diagnosis characterize a high-risk subgroup of acute promyelocytic leukemia patients
TLDR
In conclusion, FLT3-ITD size and PML-RARα transcript levels at diagnosis could contribute to improve the risk stratification in APL. Expand
The relevance of preferentially expressed antigen of melanoma (PRAME) as a marker of disease activity and prognosis in acute promyelocytic leukemia
TLDR
This study suggests that low PRAME expression defines a subgroup of APL patients with a short relapse-free survival, and this marker could be useful as a secondary marker for monitoring patients with acute promyelocytic leukemia. Expand
Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients
TLDR
This is the first description of an impaired microRNA biogenesis in human mesenchymal stromal cells from myelodysplastic syndrome patients, where DICER1 and DROSHA gene and protein downregulation correlated to a gene and microRNA abnormal expression profile, validating the animal model results previously described. Expand
Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting.
TLDR
The effect of 5-azaC in T lymphocytes is shown and its role in the allogeneic transplantation setting as an immunomodulatory drug is illustrated, describing new pathways that must be explored to prevent graft-versus-host disease. Expand
Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms.
TLDR
Peptide AppK synthesized with D-amino acids retained both activities of the natural L-enantiomer, suggesting that its mechanism of action does not involve the recognition of a proteic receptor/acceptor site on muscle cells, but possibly the binding to other structures, such as negatively-charged membrane phospholipids. Expand
Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region.
TLDR
The bactericidal and anti-endotoxic properties of pEM-2, combined with its relatively low toxicity towards eukaryotic cells, highlight it as a promising candidate for further evaluation of its antimicrobial potential in vivo. Expand
Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors
TLDR
An array-based comparative genomic hybridization analysis to compare the extent of unbalanced genomic alterations in mesenchymal stem cells from 21 myeloma patients and 12 normal donors found only MM-MSCs showed a specific pattern of ‘hot-spot’ regions with discrete (<1 Mb) genomic alterations, some of which were confirmed using fluorescence in situ hybridization (FISH). Expand
Using quantification of the PML-RARalpha transcript to stratify the risk of relapse in patients with acute promyelocytic leukemia.
TLDR
A relapse risk stratification could be established for APL patients by analyzing any associations between the risk of relapse and RQ-PCR results in different phases of treatment, comparing these data with those yielded by conventional qualitative reverse transcriptase- PCR. Expand
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