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Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery.
TLDR
This review highlights scientific advances from 1999-2003 in the emerging field of molecular genetics of polyketide and nonribosomal peptide natural products isolated from marine organisms towards the development of marine secondary metabolites as a sustainable source of new drugs.
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The cellular localization of dercitamide in the Palauan sponge Oceanapia sagittaria
TLDR
It is demonstrated that large quantities of the pyridoacridine alkaloid dercitamide (=Kuanoniamine C) are localized exclusively in bacteria-free sponge cells in the marine sponge Oceanapia sagittaria (Sollas), and are probably not produced by intracellular symbiotic organisms.
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Symbiotic Bacteria in Sponges: Sources of Bioactive Substances
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Rationally designed dual inhibitors of HIV reverse transcriptase and integrase.
Bifunctional inhibitors were designed and synthesized based on 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)a1 non-nucleoside reverse transcriptase (RT) inhibitors and diketoacid (DKA)…
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Natural products as leads for tuberculosis drug development.
TLDR
This review presents natural products and synthesized analogues with anti-mycobacterial activity published between 2006 through 2009 and reports on newly reported activities of known compounds reported during this period.
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Pathogen variation and urea influence selection and success of Streptomyces mixtures in biological control.
TLDR
In greenhouse trials, urea enhanced the effectiveness of antagonist mixtures relative to individual antagonists in controlling potato scab and all n= 2 and n = 3 antagonist-isolate combinations were synergistic in the presence of urea.
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Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways
TLDR
Findings suggest that certain polyphenolic compounds derived from A. hydaspica may be promising chemopreventive/therapeutic candidates against cancer.
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Subinhibitory Antibiotic Concentrations Mediate Nutrient Use and Competition among Soil Streptomyces
TLDR
Antibiotic as signals may mediate coevolutionary displacement among coexisting Streptomyces, thereby hindering the emergence of antibiotic resistant phenotypes and contributing to the broad understanding of the ecology and evolutionary biology of antibiotics and microbial signals in nature.
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Structure and cytotoxicity of arnamial and related fungal sesquiterpene aryl esters.
TLDR
Arnamial showed cytotoxicity against Jurkat T cells, MCF-7 breast adenocarcinoma, CCRF-CEM lymphoblastic leukemia, and HCT-116 colorectal carcinoma cells as well as the cytotoxic activity of structurally related compounds on selected human cancer cells.
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New azacyclopropene derivatives from Dysidea fragilis collected in Pohnpei.
TLDR
The sponge Dysidea fragilis from Pohnpei contained four azacyclopropene derivatives, which is the optical enantiomer of the known compound dysidazirine, and the structures of the new compounds were elucidated by interpretation of spectral data.
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