C. Sakanaka

Publications39
h-index21
Citations2,047
Highly Influential Citations76
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Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd
TLDR
It is shown that mNkd acts in a cell-autonomous manner not only to inhibit the canonical Wnt pathway but also to stimulate c-Jun-N-terminal kinase activity, consistent with a role for mNKd in the PCP pathway.
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Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function.
TLDR
CKIepsilon appears to be a positive regulator of the Wnt pathway and a link between upstream signals and the complexes that regulate beta-catenin, including Dishevelled.
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Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription
TLDR
It is shown that Axin simultaneously binds two components of the Wnt pathway, β-catenin and its negative regulator glycogen synthase kinase-3β, and can block signaling stimulated by Wnt or by adenomatous polyposis coli mutations.
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Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
TLDR
The results indicate that both Sfrp1 and TCF-4 repress Wnt signaling in breast tissue and their downregulation contributes to the activation of WNT signaling.
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On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase.
TLDR
SSTR4 appears to stimulate MAP kinase and cPLA2 in a Gi-dependent, and through a wortmannin-sensitive pathway, and it was shown that stimulation with SS14, in combination with calcium-ionophore, strongly enhanced arachidonate release from these cells.
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Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription.
TLDR
It is shown that Axin simultaneously binds two components of the Wnt pathway, beta-catenin and its negative regulator glycogen synthase kinase-3beta, to block signaling stimulated by Wnt or by adenomatous polyposis coli mutations.
View on PubMed
Casein kinase I « in the Wnt pathway : Regulation of b-catenin function
TLDR
Casein kinase I« appears to be a positive regulator of the Wnt pathway and a link between upstream signals and the complexes that regulate b-catenin, according to a study isolated from Xenopus.
Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade.
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Identification of Two Isoforms of Mouse Neuropeptide Y-Y1 Receptor Generated by Alternative Splicing
TLDR
The results suggest that the Y1β receptor is an embryonic and a bone marrow form of the NPY-Y1 receptor, which decreases in the expression during development and differentiation.
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Functional Domains of Axin
TLDR
To understand the mechanism of how Axin acts as an inhibitory molecule in the Wnt pathway, a series of mutated forms of Axin were generated and substitution of the C-terminal region with an unrelated dimerizing molecule restored its inhibitory effect on Lef-1-dependent transcription.
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