Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease
- E. Konrath, C. S. Passos, L. Klein-Júnior, A. Henriques
- Chemistry, BiologyThe Journal of pharmacy and pharmacology
- 1 December 2013
This review aims to summarize recent advances in current knowledge on alkaloids as AChE and BChE inhibitors, highlighting structure–activity relationship (SAR) and docking studies.
Investigation of the in vitro and ex vivo acetylcholinesterase and antioxidant activities of traditionally used Lycopodium species from South America on alkaloid extracts.
Indole alkaloids of Psychotria as multifunctional cholinesterases and monoamine oxidases inhibitors.
Strictosidinic acid, isolated from Psychotria myriantha Mull. Arg. (Rubiaceae), decreases serotonin levels in rat hippocampus.
Three New Monoterpene Indole Alkaloids from Psychotria umbellata Thonn.
Abstract Three new psychollatine-derived monoterpene indole alkaloids were obtained from Psychotria umbellata Thonn.: 3,4-Dehydro-18,19-β-epoxy-psychollatine (2),…
Chemical analysis, antioxidant, antichemotactic and monoamine oxidase inhibition effects of some pteridophytes from Brazil
- J. M. Andrade, C. S. Passos, R. Dresch, M. A. Kieling-Rubio, P. R. Moreno, A. Henriques
- Biology, MedicinePharmacognosy Magazine
The hypothesis was considered that phenolics and triterpenes are responsible for these pronounced activities of ferns from Brazil.
Photodegradation kinetics, cytotoxicity assay and determination by stability-indicating HPLC method of mianserin hydrochloride.
- L. L. Sfair, J. S. Graeff, C. S. Paim, C. S. Passos, M. Steppe, E. Schapoval
- 6 March 2012
A stability-indicating HPLC method for the determination of mianserin hydrochloride in coated tablets was developed and validated and the preliminary cytotoxicity in vitro against mononuclear cells was determined.
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.
Cell-based assays of BBB permeation, neurotoxicity, and neuroprotection supported the potential of compound 37 as a BBB-permeant neuroprotective agent against H2O2-induced oxidative stress with poor interaction as P-gp substrate and very low cytotoxicity.
Psychollatine, a glucosidic monoterpene indole alkaloid from Psychotria umbellata.
- V. A. Kerber, C. S. Passos, H. Verli, A. Fett-Neto, J. Quirion, A. Henriques
- ChemistryJournal of Natural Products
- 21 February 2008
A monoterpene indole alkaloid, psychollatine ( 1), was isolated from Psychotria umbellata leaves. Its structure was characterized by interpretation of spectroscopic data and by comparison of its NMR…