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Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
- I. Galve-Roperh, C. Sánchez, M. Cortés, T. Pulgar, M. Izquierdo, M. Guzmán
- Biology, Medicine
- Nature Medicine
- 1 March 2000
It is shown that intratumoral administration of Δ9-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Expand
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
It is shown that local administration of the selective CB(2) agonist JWH-133 at 50 microg/day to Rag-2(-/-) mice induced a considerable regression of malignant tumors generated by inoculation of C6 glioma cells, and showed that selective activation of the CB( 2) receptor signaled apoptosis via enhanced ceramide synthesis de novo. Expand
Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation.
- M. Caffarel, D. Sarrió, J. Palacios, M. Guzmán, C. Sánchez
- Biology, Medicine
- Cancer research
- 1 July 2006
It is shown that Delta(9)-tetrahydrocannabinol (THC), through activation of CB(2) cannabinoid receptors, reduces human breast cancer cell proliferation by blocking the progression of the cell cycle and by inducing apoptosis. Expand
The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK
The data show that GPR55 expression in human tumors from different origins correlates with their aggressiveness, and suggest that it could constitute a new biomarker and therapeutic target in oncology. Expand
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
Results show that both Δ9-tetrahydrocannabinol, the most abundant and potent cannabinoid in marijuana, and JWH-133, a non-psychotropic CB2 receptor-selective agonist, reduce tumor growth, tumor number, and the amount/severity of lung metastases in MMTV-neu mice. Expand
A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
The fair safety profile of THC, together with its possible antiproliferative action on tumour cells reported here and in other studies, may set the basis for future trials aimed at evaluating the potential antitumoral activity of cannabinoids. Expand
Δ9‐Tetrahydrocannabinol induces apoptosis in C6 glioma cells
Δ9‐Tetrahydrocannabinol (THC), the major active component of marijuana, induced apoptosis in C6.9 glioma cells, as determined by DNA fragmentation and loss of plasma membrane asymmetry. THC… Expand
Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes.
- C. Sánchez, I. Galve-Roperh, D. Rueda, M. Guzmán
- Chemistry, Medicine
- Molecular pharmacology
- 1 November 1998
Results indicate that THC produces a cannabinoid receptor-mediated stimulation of astrocyte metabolism that seems to rely on sphingomyelin hydrolysis and MAPK stimulation. Expand
Anticancer mechanisms of cannabinoids.
The current understanding of cannabinoids as antitumour agents is discussed, focusing on recent discoveries about their molecular mechanisms of action, including resistance mechanisms and opportunities for their use in combination therapy. Expand
The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas
These findings reveal the pivotal importance of GPR55 in skin tumor development, and suggest that this receptor may be used as a new biomarker and therapeutic target in squamous cell carcinomas. Expand