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Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials.
OBJECTIVE To evaluate the usefulness of preimplantation genetic screening (PGS) using fluorescence in situ hybridization (FISH) for two different indications: repetitive implantation failure (RIF)… Expand
In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study.
OBJECTIVE To determine the clinical value of preimplantation genetic diagnosis for aneuploidy screening (PGD-A) in women of advanced maternal age (AMA; between 38 and 41 years). DESIGN This was a… Expand
Mitochondrial DNA content as a viability score in human euploid embryos: less is better.
OBJECTIVE To investigate the clinical relevance of mitochondrial DNA (mtDNA) content as a viability score in human euploid embryos. DESIGN Retrospective analysis of mtDNA content of transferred… Expand
Cytological Studies of Human Meiosis: Sex-Specific Differences in Recombination Originate at, or Prior to, Establishment of Double-Strand Breaks
Meiotic recombination is sexually dimorphic in most mammalian species, including humans, but the basis for the male:female differences remains unclear. In the present study, we used cytological… Expand
The Bisphenol A Experience: A Primer for the Analysis of Environmental Effects on Mammalian Reproduction1
It is increasingly evident that environmental factors are a veritable Pandora's box from which new concerns and complications continue to emerge. Although previously considered the domain of… Expand
Implications of Sperm Chromosome Abnormalities in Recurrent Miscarriage
- C. Rubio, C. Simón, +6 authors A. Pellicer
- Biology, Medicine
- Journal of Assisted Reproduction and Genetics
- 1 May 1999
Purpose:Our purpose was to assess the existence of sperm chromosome abnormalities in recurrent pregnancy loss in an assisted reproduction program.Methods:In this prospective study, 12 sperm samples… Expand
The role of thrombophilia and thyroid autoimmunity in unexplained infertility, implantation failure and recurrent spontaneous abortion.
BACKGROUND The role of thrombophilia and thyroid autoimmunity in unexplained infertility (UI), implantation failure (IF) and recurrent spontaneous abortion (RSA) is controversial and poorly… Expand
The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
- K. Sermon, A. Capalbo, +29 authors J. Geraedts
- Biology, Medicine
- Molecular human reproduction
- 1 August 2016
STUDY QUESTION We wanted to probe the opinions and current practices on preimplantation genetic screening (PGS), and more specifically on PGS in its newest form: PGS 2.0? STUDY FINDING Consensus is… Expand
Diagnosis of human preimplantation embryo viability.
- D. Gardner, M. Meseguer, C. Rubio, N. Treff
- Medicine, Biology
- Human reproduction update
- 1 November 2015
BACKGROUND Transfer of more than a single embryo in an IVF cycle comes with the finite possibility of a multiple gestation. Even a twin pregnancy confers significant risk to both mother and babies.… Expand
Analyzing mammalian female meiosis.
The goal of this chapter is twofold: First, to acquaint the reader with the problems inherent in analyzing mammalian female meiosis and, second, to provide a step-by-step approach to mastering the… Expand