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A Bacterial Guanine Nucleotide Exchange Factor Activates ARF on Legionella Phagosomes
The intracellular pathogen Legionella pneumophilasubverts vesicle traffic in eukaryotic host cells to create a vacuole that supports replication. The dot/icm genes encode a protein secretionExpand
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The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection
Baculovirus inhibitor of apoptosis repeat-containing 1 (Birc1) proteins have homology to several germline-encoded receptors of the innate immune system. However, their function in immune surveillanceExpand
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Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites
It is unknown how Legionella pneumophila cells escape the degradative lysosomal pathway after phagocytosis by macrophages and replicate in an organelle derived from the endoplasmic reticulum. Here weExpand
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Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity
Macrophages from C57BL/6J (B6) mice restrict growth of the intracellular bacterial pathogen Legionella pneumophila. Restriction of bacterial growth requires caspase-1 and the leucine-richExpand
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Modulation of host cell function by Legionella pneumophila type IV effectors.
  • Andree Hubber, C. Roy
  • Biology, Medicine
  • Annual review of cell and developmental biology
  • 7 October 2010
Macrophages and protozoa ingest bacteria by phagocytosis and destroy these microbes using a conserved pathway that mediates fusion of the phagosome with lysosomes. To survive within phagocytic hostExpand
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A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells.
The Legionella pneumophila Dot/Icm system is a type IV secretion apparatus that transfers bacterial proteins into eukaryotic host cells. The RalF protein is a substrate engaged and translocated intoExpand
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Modulation of Rab GTPase function by a protein phosphocholine transferase
The intracellular pathogen Legionella pneumophila modulates the activity of host GTPases to direct the transport and assembly of the membrane-bound compartment in which it resides. In vitro studiesExpand
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Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake
Numerous intracellular bacterial pathogens modulate the nature of the membrane‐bound compartment in which they reside, although little is known about the molecular basis for this control. LegionellaExpand
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How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane.
Within five minutes of macrophage infection by Legionella pneumophila, the bacterium responsible for Legionnaires' disease, elements of the rough endoplasmic reticulum (RER) and mitochondria attachExpand
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Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors
Specialized secretion systems are used by many bacteria to deliver effector proteins into host cells that can either mimic or disrupt the function of eukaryotic factors. We found that theExpand
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