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Direct transesterification of all classes of lipids in a one-step reaction.
TLDR
This one-step direct transesterification procedure carried out in methanol-benzene 4:1 with acetyl chloride is superior to currently used methods not onlyBecause of its simplicity and speed, but also because of its added precision. Expand
Improved recovery of fatty acid through direct transesterification without prior extraction or purification.
  • G. Lepage, C. Roy
  • Chemistry, Medicine
  • Journal of lipid research
  • 1 December 1984
TLDR
The direct transesterification method appears to be particularly advantageous for the recovery of the highly volatile medium chain triglycerides and there is no need to add an antioxidant to protect unsaturated lipids. Expand
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
TLDR
The data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell. Expand
Paediatric Castleman disease: report of seven cases and review of the literature
TLDR
The paediatric features of the disease suggest that Castleman disease in this population could represent an earlier form of the pathology or even suggest a benign lymphoproliferative disorder. Expand
The potential of the hydrocarbon breath test as a measure of lipid peroxidation.
TLDR
The results of the hydrocarbon breath test are not influenced by prior food consumption, but both vitamin E and beta-carotene supplementation decrease hydrocarbon excretion, and the long-term use of a diet high in polyunsaturated fatty acids, such as in parenteral nutrition regimens, may result in increased hydrocarbon exhalation. Expand
Short-chain fatty acids: ready for prime time?
TLDR
Prebiotics seem to be largely mediated by SCFA, but evidence from human studies remains inconsistent, and the food industry is making a leap of faith in their efforts to commercialize prebiotics and exploit potential health benefits. Expand
Specific methylation of plasma nonesterified fatty acids in a one-step reaction.
  • G. Lepage, C. Roy
  • Chemistry, Medicine
  • Journal of lipid research
  • 1 February 1988
TLDR
The specificity of the methylation reaction for NEFA without hydrolysis of other classes of plasma lipids was substantiated with appropriate standards and this one-step specific methylation procedure is superior to currently used methods. Expand
Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers
TLDR
The clinical guidelines proposed will helpfully lead to an earlier diagnosis and the prevention of complications, and dietary counseling is needed not only to monitor fat intake and improve symptoms, but also to maintain sufficient caloric and EFA intake. Expand
Humoral Immune Mechanism of Liver Injury in Giant Cell Hepatitis With Autoimmune Hemolytic Anemia
TLDR
Widespread complement-mediated hepatocyte injury and typical C3a and C5a complement-driven liver inflammation along with Coombs-positive hemolytic anemia in GCH-AHA provide convincing evidence that systemic B-cell autoimmunity plays a central pathologic mechanism in the disease. Expand
Direct transesterification of plasma fatty acids for the diagnosis of essential fatty acid deficiency in cystic fibrosis.
TLDR
This study aimed at redefining criteria for essential fatty acid (EFA) deficiency with the use of the direct transesterification procedure and determining whether a simple assay of total fatty acids (FA) is as predictive of EFA deficiency as the FA pattern from plasma, red cell, and platelet phospholipids. Expand
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