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The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease.
BACKGROUND The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 to assist with prospective research into Alzheimer's diseaseExpand
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High performance plasma amyloid-β biomarkers for Alzheimer’s disease
To facilitate clinical trials of disease-modifying therapies for Alzheimer’s disease, which are expected to be most efficacious at the earliest and mildest stages of the disease, supportive biomarkerExpand
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Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease
Significance Beta-amyloid plaque accumulation, glucose hypometabolism, and neuronal atrophy are hallmarks of Alzheimer’s disease. However, the regional ordering of these biomarkers prior to dementiaExpand
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Radioiodinated clioquinol as a biomarker for β‐amyloid: Zn2+ complexes in Alzheimer's disease
Neocortical β‐amyloid (Aβ) aggregates in Alzheimer's disease (AD) are enriched in transition metals that mediate assembly. Clioquinol (CQ) targets metal interaction with Aβ and inhibits amyloidExpand
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Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome
Acetaminophen overdose is the leading cause of acute liver failure. One dose of 10–15 g causes severe liver damage in humans, whereas repeated exposure to acetaminophen in humans and animal modelsExpand
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Validation of fully automatic brain SPET to MR co-registration
Abstract.Fully automatic co-registration of functional to anatomical brain images using information intrinsic to the scans has been validated in a clinical setting for positron emission tomographyExpand
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High-reflectivity monomode-fibre grating filters
The fabrication and characterisation of efficient, narrowband fibre-optic filters utilising surface-relief gratings etched into monomode fibre are described. A device with 92% reflectivity and 1·8 nmExpand
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The Centiloid Scale: Standardization of amyloid imaging measures
and potentially in healthy controls via affordable and widely available multimodal-MRI. Our previous publications indicate that hippocampal volume is by itself a poor predictor of amyloid status,Expand
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Narrow-linewidth fibre laser with integral fibre grating
The fabrication and operation of an Nd3+-doped silica single-mode fibre laser using a distributed fibre grating as the feedback element is reported. The laser had a threshold of less than 2mW, aExpand
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Experimental Evaluation of a Fibre Raman Oscillator Having Fibre Grating Reflectors
We report on the construction and characterization of a novel fibre Raman oscillator which used fibre grating reflectors rather than discrete mirrors to form the Raman resonator. This was synchrono...
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