Two distinct dopamine D2 receptor genes in the European eel: molecular characterization, tissue-specific transcription, and regulation by sex steroids.
- C. Pasqualini, F. Weltzien, S. Dufour
- BiologyEndocrinology
- 1 March 2009
It is hypothesized that differences in the tissue expression pattern and hormonal regulation of eel D2A- and D2B-R gene expression could represent selective forces that have contributed to the conservation of the duplicated D2-R.
Involvement of beta(3)-adrenoceptors in mouse urinary bladder function: role in detrusor muscle relaxation and micturition reflex.
- Aurore Deba, S. Palea, C. Rouget, T. Westfall, P. Lluel
- Biology, MedicineEuropean Journal of Pharmacology
- 15 September 2009
Beta3-adrenoceptor is the predominant beta-adrenoceptor subtype in human myometrium and its expression is up-regulated in pregnancy.
To assess whether pregnancy might influence the functionality and expression of human myometrial beta(2)- and beta(3)-adrenoceptors (beta(2)- and beta(3)-AR), we performed functional, binding,…
β3-Adrenoceptor Is the Predominant β-Adrenoceptor Subtype in Human Myometrium and Its Expression Is Up-Regulated in Pregnancy
Although two populations of binding sites corresponding to β2- and β3-AR were identified in both nonpregnant and pregnant myometrium, it was found that there was a clear predominance of the β 3-AR subtype.
Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2‐adrenoceptors
- C. Rouget, L. Quinton, D. Servent
- Biology, MedicineBritish Journal of Pharmacology
- 1 November 2010
A screen was used to identify novel toxins from Dendroaspis angusticeps targeting aminergic GPCRs that may offer new candidates for the development of new tools and drugs.
Modulation of nerve-evoked contractions by β3-adrenoceptor agonism in human and rat isolated urinary bladder.
- C. Rouget, M. Rekik, T. Westfall
- Biology, ChemistryPharmacological Research
- 1 February 2014
G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors.
- Arhamatoulaye Maïga, G. Mourier, N. Gilles
- Biology, ChemistryToxicon
- 15 March 2012
Nociceptin inhibits airway microvascular leakage induced by HCl intra‐oesophageal instillation
- C. Rouget, Yong Yao Cui, C. Advenier
- Biology, MedicineBritish Journal of Pharmacology
- 1 March 2004
Airway plasma extravasation induced by intra‐oesophageal HCl instillation might be inhibited by specific stimulation of the NOP receptor with nociceptin, likely to act at a pre‐junctional level, by inhibiting tachykinin release.
Beta adrenergic modulation of spontaneous microcontractions and electrical field-stimulated contractions in isolated strips of rat urinary bladder from normal animals and animals with partial bladder…
- J. Gillespie, C. Rouget, S. Palea, C. Granato, C. Korstanje
- Biology, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 7 June 2015
In detrusor strips from both normal and obstructed animals, EFS-induced contractions were weakly affected by isoprenaline and even less so by mirabegron, while Isoprenalin-induced inhibition of microcontractions and EFS was antagonized by theβ1-AR antagonist, but not by the β2- and β3-AR antagonists.
The human near‐term myometrial β3‐adrenoceptor but not the β2‐adrenoceptor is resistant to desensitisation after sustained agonist stimulation
- C. Rouget, M. Breuiller-Fouché, M. Bardou
- Medicine, Biology
- 1 March 2004
The results indicate that β3‐ AR, but not β2‐AR, are resistant to the agonist‐induced desensitisation, which was not explained by transcriptional regulation of the receptor.
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