C. Rossant

Publications24
h-index10
Citations339
Highly Influential Citations5
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Corticotropin-Releasing Factor Type 1 and Type 2α Receptors Regulate Phosphorylation of Calcium/Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding Protein and Activation of p42/p44…
CRF exerts a key neuroregulatory control on the function of the hypothalamic-pituitary-adrenal axis. These effects are thought to be mediated primarily through activation of Gs-coupled plasma… Expand
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Phage display and hybridoma generation of antibodies to human CXCR2 yields antibodies with distinct mechanisms and epitopes
Generation of functional antibodies against integral membrane proteins such as the G-protein coupled receptor CXCR2 is technically challenging for several reasons, including limited epitope… Expand
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Effects of Redox Reagents and Arsenical Compounds on [3H]‐Cytisine Binding to Immunoisolated Nicotinic Acetylcholine Receptors from Chick Brain Containing α4 β2 Subunits
All known nicotinic receptor α subunits include a conserved disulfide bond that is essential for function and is a site for labeling via biochemical modification. In an effort to develop a universal… Expand
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Application of the Mirrorball High-Sensitivity Cytometer to Multiplexed Assays for Antibody Drug Discovery
Highly sensitive, high-throughput assay technologies are required for the identification of antibody therapeutics. Multiplexed assay systems are particularly advantageous because they allow… Expand
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Effects of redox reagents and arsenical compounds on [3H]-cytisine binding to immunoisolated nicotinic acetylcholine receptors from chick brain containing alpha 4 beta 2 subunits.
All known nicotinic receptor alpha subunits include a conserved disulfide bond that is essential for function and is a site for labeling via biochemical modification. In an effort to develop a… Expand
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Characterisation using microphysiometry of CRF receptor pharmacology.
We have assessed the utility of the Cytosensor microphysiometer for studying the pharmacology of recombinant CRF receptors. Chinese hamster ovary cells stably expressing the human CRF1 or CRF2… Expand
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10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum.
Two new compounds, 10-methoxydihydrofuscin (1) and fuscinarin (2), and one known compound, fuscin (3), have been isolated from the soil fungus Oidiodendron griseum. These compounds were found to… Expand
  • 62
Expression and characterisation of human and rat CRF2α receptors
Rat and human CRF2alpha receptors were expressed in CHO-pro5 cells and stable cell lines generated. Each receptor was characterised using [125I][tyr0]sauvagine and results compared to CRF1 receptors… Expand
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Interactions of dithiols with p-aminophenyldichloroarsine and nicotinic acetylcholine receptors.
Interactions of dithiols with p-aminophenyldichloroarsine (APA) and with Torpedo nicotinic receptors were studied using two approaches. First, the stability of dithiol-APA complexes in solution was… Expand
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A combination of in vitro techniques for efficient discovery of functional monoclonal antibodies against human CXC chemokine receptor-2 (CXCR2)
Background: Development of functional monoclonal antibodies against intractable GPCR targets. Results: Identification of structured peptides mimicking the ligand binding site, their use in panning to… Expand
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