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Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. I. Development and initial characterisation of the model
A simple and reliable animal model to quantify interleukin-1 (IL-1) production at a site of inflammation has been developed and characterised. This model involves the subcutaneous implatation ofExpand
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Increased interleukin-1 beta (IL-1 beta) concentration in gingival tissue from periodontitis patients.
Human gingival tissues from periodontitis patients were found to contain from 126 fg/mg to 2161 fg/mg interleukin-1 beta as determined by a sensitive enzyme linked immunoassay. No IL-1 beta could beExpand
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Arthritis induced by continuous infusion of hr-interleukin-1 alpha into the rabbit knee-joint.
Continuous infusion of 200 ng/day hrIL-1 alpha for 14 days into knee-joints of rabbits leads to a severe arthritis of low aggressivity. This arthritis shows simultaneously characteristics of acuteExpand
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An assay for the detection of interleukin-1 synthesis inhibitors: effects of antirheumatic drugs.
The monokines interleukin-1 beta and alpha (IL-1) play a central role in the connective tissue destruction of many chronic inflammatory diseases. A high capacity screening assay for the detection ofExpand
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IgG-stimulated and LPS-stimulated monocytes elaborate transforming growth factor type β (TGF-β) in active form
Abstract Mononuclear cells (MNC) stimulated either with lipopolysaccharide (LPS) or with surface-adsorbed IgG elaborated significant amounts of tumor necrosis factor (TNF) bioactivity, as well asExpand
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Binding Characteristics of Human Serum Amyloid P Component
Serum amyloid P comptinent (SAP), a normal human plasma glycoprotein. was found in a solid phase ELISA to have Ca2+‐dependent binding for keyhole limpet haemocyanin (KLH), pectic acid,Expand
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Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. II. Identification of (tissue) macrophages as the IL-1 producing cells and the effect of anti-inflammatory drugs
We have used our newly described mouse tissue chamber model [1], to investigate the process of IL-1 production in more detail. The inflammatory reaction in the tissue surrounding the implantedExpand
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Differential immunological response of patients with rheumatoid arthritis towards two different Epstein-Barr virus strains: inhibition of interleukin-1 release by the B95-8, but not the P3HR-1 virus
SummaryAn abnormal immune response towards the Epstein-Barr virus (EBV) has been documented in patients with rheumatoid arthritis (RA). To investigate whether these findings are due to theExpand
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Murine polyspecific antibodies. I. Monoclonal and serum anti-DNA antibodies cross-reactive with 2,4,6-trinitrophenyl derivatives.
Six anti-DNA hybridoma autoantibodies were prepared by fusing spleen cells from unimmunized MRL/MpJ/lpr/lpr female mice with BALB/c myeloma cells. The monoclonal antibodies were analyzed byExpand
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Polyarthritis in MRL 1pr/1pr mice
SummaryMice of the inbred strain MRL/MpJ-1pr/1pr are affected by a systemic autoimmune disease and a spontaneously occurring polyarthritis. To characterize the arthritis a histopathological study wasExpand
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