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Clinical significance of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver diseases.
The presence of ANCA as detected by indirect immunofluorescence was associated with the occurrence of relapses in autoimmune hepatitis, with decreased liver synthesis function in primary biliary cirrhosis and inPrimary sclerosing cholangitis, and with increased cholestasis in primary scleroses cholangsitis. Expand
Disturbed B Cell Homeostasis in Newly Diagnosed Giant Cell Arteritis and Polymyalgia Rheumatica
This study was undertaken to examine the distribution of defined B cell subsets, including effector B (Beff) cells and regulatory B (Breg) cells, in patients with GCA and patients with PMR before and after corticosteroid treatment. Expand
The formation of autoantibodies and antibodies to TNF-α blocking agents in relation to clinical response in patients with ankylosing spondylitis.
This study indicates that antibody formation to IFX or ADA is related to a decrease in efficacy and early discontinuation of anti-TNF-α treatment in AS patients and autoantibody formation does not seem to be associated with antibodies to TNF- α blocking agents. Expand
Identification of autoantibody biomarkers for primary Sjögren's syndrome using protein microarrays
The identified saliva autoantibody biomarkers may lead to a clinical tool for simple, noninvasive detection of pSS at low cost and all were successfully validated with ELISA. Expand
Diagnostic Value of Anti-Saccharomyces cerevisiae and Antineutrophil Cytoplasmic Antibodies for Inflammatory Bowel Disease: High Prevalence in Patients with Celiac Disease
The results indicate that the presence of pANCA or ASCA in the serum of patients with chronic diarrhea does not exclude celiac disease, and a prospective study is required to determine whether pAN CA and/or ASCA identify patients at risk for developing secondary autoimmune disease. Expand
Familial occurrence of subacute thyroiditis associated with human leukocyte antigen-B35.
The case described here represents the second familial incidence and largest family reported so far with occurrence of SAT in association with HLA-B35, and seems to highlight the importance of genetic influences as a risk factor for the development of SAT. Expand
Antinuclear autoantibodies are more prevalent in COPD in association with low body mass index but not with smoking history
COPD is a heterogeneous disease with respect to the prevalence of antinuclear autoantibodies, which are primarily associated with the presence of COPD and with low BMI, but not with smoking and forced expiratory volume in 1 s. Expand
Catalase and alpha-enolase: two novel granulocyte autoantigens in inflammatory bowel disease (IBD).
This study is the first to report catalase and alpha-enolase as granulocyte antigens for autoantibodies in IBD. Expand
Rapid granulomatosis with polyangiitis induced by immune checkpoint inhibition.
SIR, there is a rise in the use of immune-potentiating drugs in oncology. The immune checkpoint modulators ipilimumab [an anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4) antibody], andExpand
Anti-neutrophil cytoplasm autoantibodies (ANCA) in autoimmune liver diseases.
Anti-neutrophil cytoplasm antibodies (ANCA) are autoantibodies directed against cytopLasmic constituents of neutrophil granulocytes and monocytes that have been detected in serum from patients with inflammatory bowel diseases and autoimmune mediated liver diseases. Expand