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Comparison of spontaneous and experimentally induced canine prostatic hyperplasia.
- D. Deklerk, D. S. Coffey, B. Zirkin
- Medicine, BiologyThe Journal of clinical investigation
- 1 September 1979
The experimentally induced prostatichyperplasia is identical in pathology to the glandular hyperplasia that occurs naturally in the aging dog with intact testes, however, cystic hyperplastic condition was not produced by any of the treatments tested in young animals.
Assessment of the active-site requirements of lanosterol 14.alpha.-demethylase: evaluation of novel substrate analogs as competitive inhibitors
A partir d'3β-acetate de lanost-7-ene-3β,30-diol, synthese de 14α-allyl, 14α-propyl, 14α-vinyl, 14α-ethyl-4,4-dimethyl-5α-cholest-7-en-3β-ol et de 30-thiiran-2-yl, 30-oxiran-2-yl-lanost-7-en-3β-ol.…
Mechanism and inhibition of cytochrome P-450 aromatase.
Compilation de 81 references recentes orientees principalement sur la diminution du taux d'œstrogenes par inhibition de leur biosynthese
Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo
The Δ5-3-ketosteroid isomerase reaction: catalytic mechanism, specificity and inhibition
Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol.
Results using a radio-high performance liquid chromatography (HPLC) assay show that in rat liver microsomal preparations, with [24,25-3H]dihydrolanosterol as substrate, the compounds do indeed inhibit the biosynthesis of sterols downstream from lanosterol.
Synthesis of potential mechanism-based inactivators of lanosterol 14.alpha.-methyl demethylase
Synthese d'alkyl-14 dimethyl-4,4 cholestene-7 ol-3 a partir d'un derive de cyclopenta [1,2] phenanthro [10,1-bc] furanne via un derive de formyl-14 dimethyl-4,4 cholestene-7 ol-3. Ces composes…
Synthesis and evaluation of 10β-substituted 4-estrene-3,17-diones as inhibitors of human placental microsomal aromatase
Relationship between structure, conformation, and antischistosomal activity of nitroheterocyclic compounds.
The biochemical and chemotherapeutic effects of a number of nitroheterocyclic compounds, including niridazole and some 5-nitro-2-furyl derivatives, on Schistosoma mansoni were investigated, and compounds which had marked schistosomicidal activity had common structural and conformational features.
Inhibition and inactivation of estrogen synthetase (aromatase) by fluorinated substrate analogues.
The interaction of these compounds with the estrogen synthetase (aromatase) activity of human placental microsomes has been studied, and this substrate analogue has been shown to be converted to estrone in high yield by this enzyme system.