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Vaccines against Toxoplasma gondii: challenges and opportunities.
TLDR
Challenges with low virulence strains, especially strains with genotype II, will probably be insufficient to provide protection against the more virulent T. gondii strains, such as those with genotypes I or II, or those genotypes from South America not belonging to genotype I, II or III. Expand
Evidence for the shikimate pathway in apicomplexan parasites
TLDR
The discovery of a functional shikimate pathway in apicomplexan parasites provides several targets for the development of new antiparasite agents. Expand
Sex-Associated Hormones and Immunity to Protozoan Parasites
TLDR
The impact of sex-associated hormones on the immune system and the development and maintenance of immunity to the intracellular protozoan parasites Toxoplasma gondii, Plasmodium spp. Expand
Neuropsychiatric Disease and Toxoplasma gondii Infection
TLDR
The evidence for T. gondii-induced behavioural changes relevant to schizophrenia and depression is reviewed and potential mechanisms responsible for these changes in behaviour including the role of tryptophan metabolism and the hypothalamic-pituitary-adrenal axis are discussed. Expand
Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa.
TLDR
Leishmania parasites can survive with greatly altered sterol profiles induced by continuous treatment with low concentrations of some inhibitors and they also have some ability to utilise and metabolise host sterol, which may permit the parasites to evade treatment with sterol biosynthesis inhibitors in some clinical situations. Expand
Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection
TLDR
In outbred mice, chronic, adult acquired T. gondii infection raises questions of whether persistence of this parasite in brain can cause inflammation or neurodegeneration in genetically susceptible hosts. Expand
Evolutionary Origins of the Eukaryotic Shikimate Pathway: Gene Fusions, Horizontal Gene Transfer, and Endosymbiotic Replacements
TLDR
Phylogenies and taxon distribution suggest that the arom gene fusion event may be an ancient eukaryotic innovation, and shared derived characters support the holophyly of the Plantae lineage and a single ancestral primary plastid endosymbiosis. Expand
Human physiological and heat shock protein 72 adaptations during the initial phase of humid-heat acclimation
TLDR
Two prolonged, low-intensity exercise-heat bouts on consecutive days are sufficient to initiate physiological and HSp72 mRNA adaptations, although Hsp72 protein adaptation may require a greater exercise intensity or longer acclimation period. Expand
Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.
TLDR
Discovery and characterisation of an apicomplexan Fab I and discovery of triclosan as lead compound provide means to rationally design novel inhibitory compounds. Expand
Toxoplasma gondii tachyzoite-bradyzoite interconversion.
TLDR
A brief summary of the process of tachyzoite-bradyzoite interconverting is provided and a new method to characterize gene expression during interconversion is introduced. Expand
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