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Vaccines against Toxoplasma gondii: challenges and opportunities.
TLDR
Challenges with low virulence strains, especially strains with genotype II, will probably be insufficient to provide protection against the more virulent T. gondii strains, such as those with genotypes I or II, or those genotypes from South America not belonging to genotype I, II or III.
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Neuropsychiatric Disease and Toxoplasma gondii Infection
TLDR
The evidence for T. gondii-induced behavioural changes relevant to schizophrenia and depression is reviewed and potential mechanisms responsible for these changes in behaviour including the role of tryptophan metabolism and the hypothalamic-pituitary-adrenal axis are discussed.
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Evidence for the shikimate pathway in apicomplexan parasites
TLDR
The discovery of a functional shikimate pathway in apicomplexan parasites provides several targets for the development of new antiparasite agents.
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Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa.
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Sex-Associated Hormones and Immunity to Protozoan Parasites
TLDR
The impact of sex-associated hormones on the immune system and the development and maintenance of immunity to the intracellular protozoan parasites Toxoplasma gondii, Plasmodium spp.
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Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection
TLDR
In outbred mice, chronic, adult acquired T. gondii infection raises questions of whether persistence of this parasite in brain can cause inflammation or neurodegeneration in genetically susceptible hosts.
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Differential Modulation of TLR3- and TLR4-Mediated Dendritic Cell Maturation and Function by Progesterone
TLDR
It is demonstrated that progesterone can differentially regulate the signaling pathways employed by TLR3 and TLR4 agonists to affect costimulatory molecule expression and cytokine production.
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Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.
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Toxoplasma gondii tachyzoite-bradyzoite interconversion.
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Human physiological and heat shock protein 72 adaptations during the initial phase of humid-heat acclimation
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