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A systematic method for clinical description and classification of personality variants. A proposal.
- C. Robert Cloninger
- PsychologyArchives of general psychiatry
A systematic method for clinical description and classification of both normal and abnormal personality variants is proposed based on a general biosocial theory of personality, which implies that the underlying structure of normal adaptive traits is the same as that of maladaptive personality traits, except for schizotypal and paranoid disorders.
A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA.
Although SSAGA was designed to provide for broad phenotyping of alcoholism, review of its new features suggests its suitability for a variety of family studies, not just those focusing on substance abuse.
Variants in nicotinic receptors and risk for nicotine dependence.
This study confirms that at least two independent variants in this nicotinic receptor gene cluster contribute to the development of habitual smoking in some populations, and it underscores the importance of multiple genetic variants contributing to theDevelopment of common diseases in various populations.
Inheritance of alcohol abuse. Cross-fostering analysis of adopted men.
The inheritance of alcoholism was studied in 862 Swedish men adopted by nonrelatives at an early age. Both the congenital and postnatal backgrounds of the adoptees modify their risk for alcohol…
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.
The GSMA produced significant genomewide evidence for linkage on chromosome 2q and suggests that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
The Temperament and Character Inventory‐Revised (TCI‐R): psychometric characteristics of the French version
The psychometric characteristics of a modified version of the Cloninger's personality questionnaire, the Temperament and Character Inventory‐Revised (TCI‐R) are explored.
Prevalence and correlates of binge eating disorder in a community sample.
Temperament and character as schizophrenia-related endophenotypes in non-psychotic siblings
Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trial.
The results suggest that ondansetron (particularly the 4 microg/kg twice per day dosage) is an effective treatment for patients with early-onset alcoholism, presumably by ameliorating an underlying serotonergic abnormality.
Childhood personality predicts alcohol abuse in young adults.
- C. Robert Cloninger, S. Sigvardsson, M. Bohman
- Psychology, MedicineAlcoholism, clinical and experimental research
- 1 August 1988
High novelty-seeking and low harm avoidance were most strongly predictive of early-onset alcohol abuse; these two childhood variables alone distinguished boys who had nearly 20-fold differences in their risk of alcohol abuse.