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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
TLDR
The data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.
Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation
TLDR
A major function of dynein/dynactin in mitosis is in a kinetochore disassembly pathway that contributes to inactivation of the spindle checkpoint.
The Respective Contributions of the Mother and Daughter Centrioles to Centrosome Activity and Behavior in Vertebrate Cells
TLDR
Time-lapse fluorescence microscopy reveals that the centriole pair inherited after mitosis splits during or just after telophase, and a model, based on differences in Mt anchoring and release by the mother and daughter centrioles is proposed to explain these results.
Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint.
TLDR
This review defines and discusses the various factors that determine how long a cell remains in mitosis when it cannot satisfy the spindle assembly checkpoint and also discusses the cell's subsequent fate.
Mitotic Checkpoint Slippage in Humans Occurs via Cyclin B Destruction in the Presence of an Active Checkpoint
TLDR
It is found that in the absence of microtubules, escape from mitosis occurs in the presence of an active SAC and requires cyclin B destruction, and vertebrate cells do not adapt to the SAC.
The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
TLDR
The data reveal that molecules in or near the unattached kinetochore of a monooriented PtK1 chromosome inhibit the metaphase-anaphase transition.
Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis
TLDR
It is shown that many of the Kinetochore fibers (K-fibers) in centrosomal Drosophila S2 cells are formed by the kinetochores, and that centrosomes facilitate the proper orientation of K-f fibers toward spindle poles by integrating them into a common spindle.
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle
TLDR
It is concluded that vertebrate somatic cells possess a metaphase-anaphase checkpoint control that monitors sister kinetochore attachment to the spindle, and that the chromosomes move poleward during anaphase.
Kinetochore Dynein Is Required for Chromosome Motion and Congression Independent of the Spindle Checkpoint
TLDR
Dynein-antibody microinjection and the RNAi of ZW10 are used to explore the role of KD in chromosome behavior during mitosis in mammals and find that depleting or inhibiting KD prevents the rapid poleward motion of attaching kinetochores but not Kinetochore fiber (K fiber) formation.
Centrosome-independent mitotic spindle formation in vertebrates
TLDR
It is shown that this method can be used to reproducibly ablate the centrosome as a functional entity, and that after destruction the microtubules associated with the ablated centrosomes disassemble.
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