The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
- Silke Hauf, R. Cole, J. Peters
- BiologyJournal of Cell Biology
- 28 April 2003
The data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.
Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation
A major function of dynein/dynactin in mitosis is in a kinetochore disassembly pathway that contributes to inactivation of the spindle checkpoint.
The Respective Contributions of the Mother and Daughter Centrioles to Centrosome Activity and Behavior in Vertebrate Cells
- M. Piel, P. Meyer, A. Khodjakov, C. Rieder, M. Bornens
- BiologyJournal of Cell Biology
- 17 April 2000
Time-lapse fluorescence microscopy reveals that the centriole pair inherited after mitosis splits during or just after telophase, and a model, based on differences in Mt anchoring and release by the mother and daughter centrioles is proposed to explain these results.
Mitotic Checkpoint Slippage in Humans Occurs via Cyclin B Destruction in the Presence of an Active Checkpoint
- Daniela A. Brito, C. Rieder
- BiologyCurrent Biology
- 20 June 2006
The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
- C. Rieder, R. Cole, A. Khodjakov, G. Sluder
- BiologyJournal of Cell Biology
- 2 August 1995
The data reveal that molecules in or near the unattached kinetochore of a monooriented PtK1 chromosome inhibit the metaphase-anaphase transition.
Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis
- H. Maiato, C. Rieder, A. Khodjakov
- BiologyJournal of Cell Biology
- 6 December 2004
It is shown that many of the Kinetochore fibers (K-fibers) in centrosomal Drosophila S2 cells are formed by the kinetochores, and that centrosomes facilitate the proper orientation of K-f fibers toward spindle poles by integrating them into a common spindle.
Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle
- C. Rieder, A. Schultz, R. Cole, G. Sluder
- BiologyJournal of Cell Biology
- 1 December 1994
It is concluded that vertebrate somatic cells possess a metaphase-anaphase checkpoint control that monitors sister kinetochore attachment to the spindle, and that the chromosomes move poleward during anaphase.
Kinetochore Dynein Is Required for Chromosome Motion and Congression Independent of the Spindle Checkpoint
- Zhenye Yang, U. Tulu, P. Wadsworth, C. Rieder
- BiologyCurrent Biology
- 5 June 2007
The Sudden Recruitment of γ-Tubulin to the Centrosome at the Onset of Mitosis and Its Dynamic Exchange Throughout the Cell Cycle, Do Not Require Microtubules
- A. Khodjakov, C. Rieder
- BiologyJournal of Cell Biology
- 9 August 1999
These data are the first to characterize the dynamics of centrosome-associated γ-tubulin in vertebrate cells in vivo and to demonstrate the microtubule-independent nature of these dynamics.
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