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Effects of vasectomy surgery and meloxicam treatment on faecal corticosterone levels and behaviour in two strains of laboratory mouse
Abstract Behaviour was assessed in 32 C57BL/6JCrl and 32 C3H/HeN male mice 1 h following vasectomy; saline or meloxicam was administered 30 min prior to surgery at 5, 10, or 20 mg kg−1. Faeces were… Expand
Anaesthesia and Post-operative Analgesia following Experimental Surgery in Laboratory Rodents: Are we Making Progress?
Current attitudes to the use of animals in biomedical research require that any pain or distress should be minimised. This can often be achieved by the use of appropriate anaesthetic and analgesic… Expand
Reported analgesic administration to rabbits undergoing experimental surgical procedures
BackgroundIt has become widely accepted that whenever animals are used in scientific procedures, the 3Rs principle of replacement, reduction and refinement described by William Russell and Rex Burch… Expand
The power of automated behavioural homecage technologies in characterizing disease progression in laboratory mice: A review
- C. Richardson
- 1 February 2015
Behavioural changes that occur as animals become sick have been characterized in a number of species and include the less frequent occurrence of ‘luxury behaviours’ such as playing, grooming and… Expand
Reported analgesic and anaesthetic administration to rodents undergoing experimental surgical procedures
A structured literature review was carried out to assess recent trends in the administration of analgesics and anaesthetics to laboratory rats and mice undergoing surgical procedures. The… Expand
Behavioural effects of ovariohysterectomy and oral administration of meloxicam in laboratory housed rabbits.
- M. Leach, Sandra Allweiler, C. Richardson, J. Roughan, R. Narbe, P. Flecknell
- Research in veterinary science
- 1 October 2009
This study aimed to develop a behaviour-based pain assessment system for rabbits following ovariohysterectomy. Behaviour was analysed to assess the severity and duration of pain induced and determine… Expand
Are We Looking in the Wrong Place? Implications for Behavioural-Based Pain Assessment in Rabbits (Oryctolagus cuniculi) and Beyond?
Background Successful observation of behaviour depends upon knowing both which behaviours to look for and focusing on the appropriate areas of the body to observe them. Behaviour based scoring… Expand
Evaluation of the efficacy of a novel electronic pain assessment device, the Pain Gauge®, for measuring postoperative pain in rats
One of the major challenges for individuals working with laboratory animals is the recognition and alleviation of pain. The Pain Gauge® is marketed as a pain assessment device that measures… Expand
Reported analgesic administration to rabbits, pigs, sheep, dogs and non-human primates undergoing experimental surgical procedures
Reported analgesic use following experimental surgery is low in rodents and there has been little published information on the frequency of analgesic use in other laboratory species. A structured… Expand
Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.
- Anna L. Smith, Julia C Whitehall, +29 authors L. Greaves
- Biology, Medicine
- Nature cancer
- 21 September 2020
Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA (mtDNA) mutations increase with age in human colorectal epithelium and are prevalent in colorectal tumours, but whether… Expand