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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.
Corticosteroids, calcium ionophores and anti-CD3 monoclonal antibodies kill mouse thymocytes incubated in vitro. Cell death is preceded by extensive DNA fragmentation into oligonucleosomal subunits.Expand
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Analysis of apoptosis by propidium iodide staining and flow cytometry
Since its introduction, the propidium iodide (PI) flow cytometric assay has been widely used for the evaluation of apoptosis in different experimental models. It is based on the principle thatExpand
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Glucocorticoid‐induced leucine zipper (GILZ): a new important mediator of glucocorticoid action
Glucocorticoids (GCs) represent the mainstay of current anti‐inflammatory and immunosuppressive strategies, mediating effects that mostly result in transcriptional regulation of glucocorticoidExpand
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A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis.
By comparing untreated and dexamethasone-treated murine T cell hybridoma (3DO) cells by the differential display technique, we have cloned a new gene, GITR (glucocorticoid-induced tumor necrosisExpand
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Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10.
Glucocorticoids and interleukin 10 (IL-10) prevent macrophage activation. In murine lymphocytes, glucocorticoids induce expression of glucocorticoid-induced leucine zipper (GILZ), which prevents theExpand
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Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
Glucocorticoid-induced tumor necrosis factor receptor (GITR) on T cells and its natural ligand, GITRL, on accessory cells contribute to the control of immune homeostasis. Here we show that reverseExpand
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Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations
GITR (glucocorticoid‐induced TNFR family related gene) is a member of the TNFR superfamily (TNFRSF) that is expressed in different cell types, including T lymphocytes. Because of a high homology inExpand
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Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New
Pathogenic mechanisms underlying the development of systemic lupus erythematosus (SLE) are very complex and not yet entirely clarified. However, the pivotal role of T lymphocytes in the induction andExpand
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GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling.
Tsc22d3 coding for glucocorticoid-induced leucine zipper (GILZ) was initially identified as a dexamethasone-responsive gene involved in the control of T lymphocyte activation and apoptosis. However,Expand
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GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily
Glucocorticoid‐induced TNFR‐related gene (GITR; TNFRSF18), a receptor belonging to the TNFR superfamily (TNFRSF), is activated by GITRL. GITR is expressed at low levels on resting responder TExpand
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