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Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals.
TLDR
The assay was incapable of providing a clear indication of whether some chemicals were mutagens; these were benzyl alcohol, 1,4-dichlorobenzene, phenol, succinic acid-2,2-dimethyl hydrazide, and toluene.
Mouse lymphoma thymidine kinase gene mutation assay: Follow‐up meeting of the international workshop on Genotoxicity testing—Aberdeen, Scotland, 2003—Assay acceptance criteria, positive controls, and
TLDR
The Mouse Lymphoma Assay (MLA) Workgroup reached consensus on the acceptance criteria for both the agar and microwell versions of the MLA and on criteria to define an acceptable positive control response.
Genotoxicity studies with pure trans-capsaicin.
L5178Y mouse lymphoma cell mutation assay results with 41 compounds
TLDR
Of the 41 chemicals examined for this report, 8 were equivocal in the rodent bioassay, and 7 were questionable in the MOLY assay, and if these chemicals are eliminated from an analysis of concordance, the remaining 26 chemicals lead to a concordances of 69% with a sensitivity of 71%.
Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors
TLDR
Rat liver S9 mix was not a requirement for the mutagenic activity of 1,2‐propylene oxide, whereas the liver preparation markedly enhanced both the cytotoxicity and mutagenicity of vinylidene chloride.
Genotoxic activity in microorganisms of tetryl, 1,3-dinitrobenzene and 1,3,5-trinitrobenzene.
TLDR
In this segment of a programme initiated by military authorities, the genotoxic potential of three nitroaromatic compounds, which have found significant use in explosive preparations, has been demonstrated.
Responses of the L5178Y mouse lymphoma cell forward mutation assay. V: 27 coded chemicals
Twenty‐seven chemicals were tested for their mutagenic potential in the L5178Y tk+/tk− mouse lymphoma cell forward mutation assay using procedures based upon those described by McGregor et al.
Mouse lymphoma thymidine kinase gene mutation assay: Follow‐up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000
TLDR
The Mouse Lymphoma Assay Workgroup of the International Workshop on Genotoxicity Test Procedures held a second harmonization meeting just prior to the U.S. Environmental Mutagen Society Meeting in New Orleans, LA, in April 2000 and unanimously agreed that the relative total growth (RTG) should be used as the cytotoxicity measure for concentration selection and data evaluation.
Reactivity of catecholamines and related substances in the mouse lymphoma L5178Y cell assay for mutagens
TLDR
Using the L5178Y mouse lymphoma cell thymidine kinase locus and the Salmonella his locus assays, the mutagenic potentials of several catecholamines and related compounds were examined and limited DNA association studies of 14C‐dopamine suggest interactions in L5 178Y andSalmonella cells and in mouse liver.
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