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Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures
Treatment of macrophage cultures with purified bacterial hsp increased the steady-state levels of cytokine mRNA for interleukin-1 alpha (IL-1alpha), IL-1 beta, IL-6, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor as well as supernatant IL- 1 secretion, suggesting that bacterial hSp might modulate immunity by rapidly and directly increasing cytokine production in macrophages.
Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter
The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and
CYP2A6- and CYP2A13-Catalyzed Metabolism of the Nicotine Δ5′(1′)Iminium Ion
It is confirmed that the nicotine Δ5′(1′)iminium ion is an inactivator of both CYP2A6 and CYP1A13, and inactivation depends on time, concentration, and the presence of NADPH.
Metallo-β-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone.
The findings with respect to MBLAC1 as a potentially exclusive, high-affinity binding partner of ceftriaxone in the CNS, and the path forward in the development of novel, MBLac1-based therapeutics are discussed.
Nucleus Accumbens Fast-Spiking Interneurons Constrain Impulsive Action
These experiments provide strong evidence that NAc FSIs constrain impulsive actions, most likely through GABA-mediated synaptic inhibition of medium spiny projection neurons.
Crystal structure of guanidinium nitroprusside, [CN3H6]2[Fe(CN)5NO], and barium nitroprusside trihydrate, Ba[Fe(CN)5NO]•3H2O
Le premier compose du titre cristallise dans Pnma avec affinement jusqu'a 0,036. Le second compose cristallise dans Pbcm avec affinement jusqu'a 0,017. Les interactions ioniques entre cations et
Legionella pneumophila heat‐shock protein‐induced increase of interleukin‐1β mRNA involves protein kinase C signalling in macrophages
It is demonstrated that Lp‐hsp 60 rapidly increases the steady‐state level of IL‐1β mRNA, possibly through a cell surface receptor system involving a PKC‐dependent signalling pathway.
Quantitative reverse transcription-PCR analysis of Legionella pneumophila-induced cytokine mRNA in different macrophage populations by high-performance liquid chromatography
The responses of macrophages to bacterial attachment in terms of cytokine mRNA levels were readily quantitated by the reverse transcription-PCR assay and showed different levels of responsiveness of distinct macrophage populations to L. pneumophila attachment, and this could be related to the characteristic nature of the Macrophage type examined.
DNA analysis for phospholipase A2 coding sequences of Mycoplasma hominis isolated from women with a normal pregnancy and women with a pregnancy complicated by preterm labour
Whatever its role in preterm labour, Mycoplasma hominis is not involved in causing an increase of prostaglandin synthesis and chromosomal DNA of M. hominis contains sequences coding for PLA2.