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Chemical synthesis, structure–activity relationship, and properties of shepherin I: a fungicidal peptide enriched in glycine-glycine-histidine motifs
Results of Shepherin I (Shep I) shed light on the chemistry, structural requirements for activity, and other properties of candidacidal glycine-rich peptides and show that Shep Ia may have strong potential for use in topical application. Expand
Acanthoscurrin fragment 101–132: Total synthesis at 60°C of a novel difficult sequence
This work describes a new difficult sequence, contributes to understanding stepwise solid‐phase synthesis of this type of peptide and shows that, at least while protected and linked to a resin, this GRP's glycine‐rich motif presents an early tendency to assume β‐sheet structures. Expand
Venom of the Peruvian snake Bothriopsis oligolepis: Detection of antibacterial activity and involvement of proteolytic enzymes and C‐type lectins in growth inhibition of Staphylococcus aureus
It is revealed that the venom of the Peruvian snake Bothriopsis oligolepis displays antibacterial activity and that the isolated SVMP, SVSP and C‐type lectin are associated to its ability to inhibit the growth of S. aureus. Expand
Hb40-61a: Novel analogues help expanding the knowledge on chemistry, properties and candidacidal action of this bovine α-hemoglobin-derived peptide.
It is indicated that the central target of Hb40-61a in Candida cells is the plasma membrane and that this synthetic hemocidin should be considered as a potential candidacidal for topic uses. Expand
Micrurus spixii venom was studied after fractionation by Sephadex G-100 SF gel filtration chromatography. Several enzymatic activities and biological effects were investigated in whole venom andExpand
The C-Terminal Fragment of Acanthoscurrin is a Difficult Sequence
Cesar Remuzgo, Gustavo F. S. Andrade, Maria L. A. Temperini, Sirlei Daffre and M. Teresa M. Miranda Departments of Biochemistry and Fundamental Chemistry, Institute of Chemistry, Av. Prof. LineuExpand
Comparison of procedures for directly obtaining protected peptide acids from peptide‐resins
The preparation of small‐sized protected peptide acids related to cholecystokinin and gomesin was attempted using peptide‐Kaiser oxime resins (KOR) as starting materials and DBU‐catalysed peptide detachment from KOR was the most efficient. Expand