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Neprilysin content is reduced in Alzheimer brain areas
TLDR
The content of the neutral endopeptidase neprilysin, an enzyme which is capable of degrading βamyloid protein, is lowest in AD brain areas most vulnerable to senile plaque development, namely the hippocampus and midtemporal gyrus, but is highest in the caudate and peripheral organs resistant to plaque formation. Expand
Hippocampus selectively supports episodic memory retrieval
Disruption of Hoxb8 gene leads to obsessive grooming behavior.
  • C. Reilly
  • Psychology, Medicine
  • Journal of neurology
  • 1 April 2002
Nogo-A is the inhibitor of CNS axon regeneration.
Astrocytes act as signal transducer in neuronal activation and cerebral arteriole vasodilation
  • C. Reilly
  • Medicine
  • Journal of Neurology
  • 1 March 2003
TLDR
A novel mechanism in which activated neurons indirectly trigger vasodilation through the coupling of astrocytes with these neurons and adjacent cerebral arterioles is suggested, which confirms the key importance played by the neuron-to-astrocyte signalling pathway in regulating local blood flow of cerebral arteriola. Expand
β-amyloid of Alzheimer’s disease activates an apoptotic pathway via caspase-8
  • C. Reilly
  • Medicine
  • Journal of Neurology
  • 21 February 2000
TLDR
Test the hypothesis that Aβ activates an apoptotic pathway in neurons similar to that associated with the Fas/Tumour Necrosis Factor Receptor (Fas/TNFR) family of death receptors, which resembles the type of activation-induced programmed cell death triggered by the cytokine Fas ligand. Expand
Cortical spreading depression is linked to pain transmission by the trigeminal nerve
  • C. Reilly
  • Medicine
  • Journal of Neurology
  • 28 July 2014
TLDR
A link between the visual aura and pain is established by establishing that CSD triggers trigeminal afferents in a rat migraine model, and Bolay et al. point out that this mechanism accounts for the increased vasodilation associated with migraine headaches, and links the neurometabolic activity of the brain with the transmission of cephalic pain by the trigemINAL nerve. Expand
Astrocytes instruct stem cells to differentiate into neurons
  • C. Reilly
  • Medicine
  • Journal of Neurology
  • 1 July 2002
Textbooks in neurophysiology generally inform us that glial cells represent a minor – albeit important – cellular component within the hierarchy of the mammalian brain. The humble role assigned toExpand
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