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On the integration of alcohol-related quantitative trait loci and gene expression analyses.
BACKGROUND Quantitative trait loci (QTLs) have been detected for a wide variety of ethanol-related phenotypes, including acute and chronic ethanol withdrawal, acute locomotor activation, and ethanolExpand
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Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: A urocortin1-independent mechanism
A common expression of neuroadaptations induced by repeated exposure to addictive drugs is a persistent sensitized behavioral response to their stimulant properties. Neuroplasticity underlyingExpand
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Sensitivity to rewarding or aversive effects of methamphetamine determines methamphetamine intake
Amphetamines have rewarding and aversive effects. Relative sensitivity to these effects may be a better predictor of vulnerability to addiction than sensitivity to one of these effects alone. WeExpand
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Preclinical evidence implicating corticotropin‐releasing factor signaling in ethanol consumption and neuroadaptation
The results of many studies support the influence of the corticotropin‐releasing factor (CRF) system on ethanol (EtOH) consumption and EtOH‐induced neuroadaptations that are critical in the addictionExpand
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Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice
RationaleExposure to stressors promotes ethanol (EtOH) consumption and enhances drug craving during abstinence. Corticotropin-releasing factor (CRF), and in particular, CRF actions via type 1 CRFExpand
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Asteroid Impact and Deflection Assessment mission
Abstract The Asteroid Impact and Deflection Assessment (AIDA) mission will be the first space experiment to demonstrate asteroid impact hazard mitigation by using a kinetic impactor to deflect anExpand
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Sensitivity to psychostimulants in mice bred for high and low stimulation to methamphetamine
Methamphetamine (MA) and cocaine induce behavioral effects primarily through modulation of dopamine neurotransmission. However, the genetic regulation of sensitivity to these two drugs may be similarExpand
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Multiple Cross Mapping (MCM) markedly improves the localization of a QTL for ethanol‐induced activation
This study examines the use of multiple cross mapping (MCM) to reduce the interval for an ethanol response QTL on mouse chromosome 1. The phenotype is the acute locomotor response to a 1.5‐g/kg i.p.Expand
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Transcriptome analysis of the murine forelimb and hindlimb autopod
To gain insight into the coordination of gene expression profiles during forelimb and hindlimb differentiation, a transcriptome analysis of mouse embryonic autopod tissues was performed usingExpand
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Intracranial self-stimulation in FAST and SLOW mice: effects of alcohol and cocaine
RationaleSensitivity to the stimulant and rewarding effects of alcohol may be genetically correlated traits that predispose individuals to develop an alcohol use disorder.ObjectiveThis study aimed toExpand
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