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Latest Advances in Understanding Preeclampsia
Recent work on the causes of preeclampsia is summarized, which reveals a new mode of maternal immune recognition of the fetus, relevant to the condition, and circulating factors derived from the placenta are now better understood.
Presence of fetal DNA in maternal plasma and serum
Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis
Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success
Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the condition has an…
Preeclampsia: an excessive maternal inflammatory response to pregnancy.
Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2.
It is demonstrated that trophoblast expresses both paternally and maternally inherited HLA-C surface proteins and that maternal KIR AA frequencies are increased in affected pregnancies only when the fetus has more group 2 Hla-C genes than the mother, raising the possibility that there is a deleterious allogeneic effect stemming from paternal C2.
Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis.
Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma.
Noninvasive fetal RhD genotyping can be performed rapidly and reliably with the use of maternal plasma beginning in the second trimester of pregnancy.
NK cells and human pregnancy--an inflammatory view.