• Publications
  • Influence
Diagnosis and management of work-related asthma: American College Of Chest Physicians Consensus Statement.
TLDR
The substantial prevalence of WRA supports consideration of the diagnosis in all who present with new-onset or worsening asthma, followed by appropriate investigations and intervention including consideration of other exposed workers. Expand
Isocyanate Exposures in Autobody Shop Work: The SPRAY Study
TLDR
Despite improvements in autobody shop materials, practices, and controls, there are still opportunities for substantial exposures to isocyanate, and the frequency, duration, and intensity of isOCyanate exposures are outlined. Expand
An official american thoracic society statement: work-exacerbated asthma.
TLDR
Work-exacerbated asthma is a common and underrecognized adverse outcome resulting from conditions at work and should be considered in any patient with asthma that is getting worse or who has work-related symptoms. Expand
Skin Exposure to Isocyanates: Reasons for Concern
TLDR
Combined animal and human research is needed to better understand the role of skin exposure in human isocyanate asthma and to improve diagnosis and prevention, and sufficient evidence already exists to justify greater emphasis on the potential risks of isOCyanate skin exposure and the importance of preventing such exposures at work and during consumer use of certain isocianates. Expand
A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge.
TLDR
A novel mouse model of diisocyanate-induced asthma is established in which lung inflammation reminiscent of that seen in human asthma is generated after inhaled antigen challenge and should provide insight into this common form of occupational disease. Expand
Diisocyanate asthma: clinical aspects and immunopathogenesis.
TLDR
It is anticipated that greater understanding of the immunopathogenesis of diisocyanate asthma, including the initial cell/diisOCyanate reactions, should lead to clinically useful markers of exposure and early disease. Expand
Determinants of isocyanate exposures in auto body repair and refinishing shops.
TLDR
As part of the Survey of Painters and Repairers of Auto bodies by Yale (SPRAY), the determinants of isocyanate exposure in auto body repair shops were evaluated and identified the shop annual income was the most important determinant. Expand
Sick-building syndrome
TLDR
In assessment of patients with SBS complaints, specific building-related illnesses suggested by history or physical examination should be ruled out and changes such as ventilation improvements and reduction of sources of environmental contamination should be initiated even if specific aetiological agents have not been identified. Expand
Official American Thoracic Society technical standards: spirometry in the occupational setting.
TLDR
Recommendations are provided for the performance and interpretation of workplace spirometry that are particularly important in the workplace where inhalation exposures can affect lung function and cause or exacerbate lung diseases, such as asthma, chronic obstructive pulmonary disease, or fibrosis. Expand
Mouse models of diisocyanate asthma.
TLDR
This Perspective will discuss the findings and address key and glutathione S-transferase haplotypes that have hindered progress in understanding diisocyated with diisocyanate asthma, but this has not been conanate asthma and in developing better diagnostic tools. Expand
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