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  • Influence
Kinetics, Pharmacokinetics, and Regulation of l‐Carnitine and Acetyl‐l‐carnitine Metabolism
  • C. Rebouche
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1 November 2004
Abstract: In mammals, the carnitine pool consists of nonesterified l‐carnitine and many acylcarnitine esters. Of these esters, acetyl‐l‐carnitine is quantitatively and functionally the mostExpand
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Carnitine function and requirements during the life cycle
  • C. Rebouche
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 December 1992
l‐Carnitine has been described as a “conditionally essential” nutrient for humans. Segments of the human population suggested as having a requirement for carnitine include infants (premature andExpand
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Carnitine metabolism and its regulation in microorganisms and mammals.
In procaryotes, L-carnitine may be used as both a carbon and nitrogen source for aerobic growth, or the carbon chain may be used selectively following cleavage trimethylamine. Under anaerobicExpand
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Tissue distribution of carnitine biosynthetic enzymes in man.
The distribution in human tissues of enzymes which convert epsilon-N-trimethyl-L-lysine to L-carnitine was studied. Existing methodology was modified and new procedures were developed to measureExpand
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Carnitine status of lactoovovegetarians and strict vegetarian adults and children.
Because carnitine is contained primarily in meats and dairy products, vegetarian diets provide a model for assessing the impact of prolonged low carnitine intake on carnitine status. Plasma carnitineExpand
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Carnitine movement across muscle cell membranes. Studies in isolated rat muscle.
  • C. Rebouche
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 15 November 1977
L-Carnitine uptake and exodus was studied in rat extensor digitorum longus muscle in vitro. A saturable transport process was observed, which had an apparent Km of 60 micron and V of 22 nmol/h per gExpand
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Carnitine metabolism and deficiency syndromes.
L-Carnitine is an essential cofactor in transfer of long-chain fatty acids across the inner mitochondrial membrane. L-Carnitine is present in living systems in free form and as short-chain andExpand
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Carnitine metabolism and function in humans.
It is apparent from the foregoing discussion that carnitine plays an essential role in human intermediary metabolism. The question of a dietary requirement for carnitine, particularly for the humanExpand
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Sodium gradient-stimulated transport of L-carnitine into renal brush border membrane vesicles: kinetics, specificity, and regulation by dietary carnitine.
L-Carnitine transport by rat renal brush border membrane vesicles was stimulated by a Na+ gradient (extravesicular greater than intravesicular). Total carnitine entry was 2.7 and 3.2 times higher atExpand
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Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes. Evidence for alterations in tissue carnitine transport.
The human primary carnitine deficiency syndromes are potentially fatal disorders affecting children and adults. The molecular etiologies of these syndromes have not been determined. In thisExpand
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