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The Leishmania genome comprises 36 chromosomes conserved across widely divergent human pathogenic species.
All the physical linkage groups constituting the genome of Leishmania infantum have been identified for the first time by hybridization of specific DNA probes to pulsed field gradient-separated chromosomes, suggesting that conservation of the chromosome structure may be critical for this human pathogen.
Geographical distribution and epidemiological features of Old World cutaneous leishmaniasis foci, based on the isoenzyme analysis of 1048 strains
- F. Pratlong, J. Dereure, +6 authors J. Dedet
- Biology, MedicineTropical medicine & international health : TM…
- 1 September 2009
A series of 1048 Leishmania strains from Old World cutaneous leishmaniasis foci, isolated between 1981 and 2005, were studied by isoenzyme analysis and the taxonomic status of this taxon was revised.
Leishmania infections: Molecular targets and diagnosis.
- M. Akhoundi, T. Downing, +10 authors D. Sereno
- Biology, MedicineMolecular aspects of medicine
- 1 October 2017
A classification method based on the suitability of well-studied molecular markers for typing the 21 known Leishmania species pathogenic to humans is proposed, which can be applied to newly discovered species and to hybrid strains originating from inter-species crosses.
Conserved linkage groups associated with large-scale chromosomal rearrangements between Old World and New World Leishmania genomes.
Results show that large-scale chromosomal rearrangements occurred during the evolution of the genus Leishmania, and that the three main groups of pathogenic species are characterized by different chromosome numbers.
Autochthonous disseminated dermal and visceral leishmaniasis in an AIDS patient, southern Thailand, caused by Leishmania siamensis.
- Lertwut Bualert, Wiwat Charungkiattikul, +7 authors S. Leelayoova
- Biology, MedicineThe American journal of tropical medicine and…
- 1 May 2012
We report the first establishment of in vitro cultivation and genotypic characterization of Leishmania siamensis isolated from an autochthonous disseminated dermal and visceral leishmaniasis in a…
Development of a molecular tool for the identification of Leishmania reservoir hosts by blood meal analysis in the insect vectors.
- N. Haouas, B. Pesson, R. Boudabous, J. Dedet, H. Babba, C. Ravel
- Medicine, BiologyThe American journal of tropical medicine and…
- 1 December 2007
A molecular tool for the identification of blood meals of phlebotomine sand flies is developed based on specific amplification and sequencing of the blood meal-derived single copy prepronociceptin (PNOC) gene, which is used as a target in phylogenetic studies of mammals.
Phlebotomus sergenti (Parrot, 1917) identified as Leishmania killicki host in Ghardaïa, south Algeria.
These findings strongly suggest that the human cutaneous leishmaniases caused by L. killicki is a zoonotic disease with P. sergenti sand flies acting as hosts and vectors and gundi rodents as reservoirs.
First report of genetic hybrids between two very divergent Leishmania species: Leishmania infantum and Leishmania major.
- C. Ravel, S. Cortes, F. Pratlong, F. Morio, J. Dedet, L. Campino
- Biology, MedicineInternational journal for parasitology
- 1 November 2006
This is the first report of genetic hybrids occurring between such phylogenetically and epidemiologically distant species of Leishmania, and raises questions about the frequency of such cross-species genetic exchange in natural conditions, modalities of hybrid transmission, their long term maintenance as well as the consequences of these transfers on phenotypes such as drug resistance or pathogenicity.
First Report of Leishmania infantum in French Guiana: Canine Visceral Leishmaniasis Imported from the Old World
- B. Rotureau, C. Ravel, C. Aznar, B. Carme, J. Dedet
- Biology, MedicineJournal of Clinical Microbiology
- 1 March 2006
The first two cases of canine visceral leishmaniasis in French Guiana are described, demonstrating the intercontinental transportation theory for L. infantum.
Phlebotomine sand flies (Diptera: Psychodidae) associated with changing patterns in the transmission of the human cutaneous leishmaniasis in French Guiana.
- F. Fouque, P. Gaborit, +4 authors J. Dedet
- Biology, MedicineMemorias do Instituto Oswaldo Cruz
- 1 February 2007
Between March 2000 and December 2001 a survey of the sand flies of French Guiana was carried out during 14 nights of captures with CDC light-traps and Malaise traps, and resulted in the collection of 2245 individuals of 38 species.