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3H-Spiroperidol binding to dopamine receptors in rat striatal membranes: influence of loxapine and its hydroxylated metabolites.
The effects of loxapine and its hydroxylated metabolites 7-hydroxyloxapine and 8-hydroxyloxapine on 3H-spiroperidol binding to rat striatal membranes were investigated. Whereas 7-hydroxyloxapine and… Expand
The anticonvulsant action of carbon dioxide: interaction with reserpine and inhibitors of carbonic anhydrase.
The anticonvulsant actions of CO2 and inhibitors of carbonic anhydrase show the following similarities : 1) they are antagonized by reserpine in both rats and mice ; 2) action is restored by the… Expand
The anticonvulsant action of the carbonic anhydrase inhibitor methazolamide: possible involvement of a noradrenergic mechanism.
Abstract In contrast to previous concepts, the noradrenergic mechanism required for the anticonvulsant action of inhibitors of carbonic anhydrase in mice is extracerebral on the basis of the… Expand
Interaction of amoxapine with muscarinic cholinergic receptors: an in vitro assessment.
- J. Coupet, S. Fisher, C. Rauh, F. Lai, B. Beer
- Chemistry, Medicine
- European journal of pharmacology
- 7 June 1985
Amoxapine, an antidepressant with a rapid onset of therapeutic efficacy and great utility in psychotic depression, has been reported to produce anticholinergic side effects in man similar to those… Expand
The relation between monoamines in brain and the anticonvulsant action of inhibition of carbonic anhydrase.
Depletion of norepinephrine and dopamine in brain by α-methyltryrosine had no effect on the anticonvulsant potency of methazolamide in rats and only a slight antagonist action in mice. Depletion of… Expand
The mechanism of the antagonistic action of reserpine on the anticonvulsant effect of inhibitors of carbonic anhydrase.
- W. D. Gray, C. Rauh, R. W. Shanaha
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 March 1963
Antagonism of the anticonvulsant action of inhibitors of carbonic anhydrase in mice by reserpine was shown not to be due to any effect of this agent on brain with respect to 1) the concentration of… Expand
The anticonvulsant action of inhibitors of carbonic anhydrase: relation to endogenous amines in brain.
Five hours after the administration of graded amounts of reserpine to mice, measurements were made of 1) the concentration of norepinephrine, 5-hydroxytraptamine and dopamine in brain, 2)… Expand
2-Chloro-11-(1-piperazinyl)dibenz[b, f] [1, 4]oxazepine (amoxapine), an antidepressant with antipsychotic properties--a possible role for 7-hydroxyamoxapine.
The anticonvulsant action of inhibitors of carbonic anhydrase: site and mode of action in rats and mice.
The concentrations of inhibitor in brain, red cells and plasma were measured enzymatically 5 min after i.v. administration of the carbonic anhydrase inhibitors… Expand
Neuropeptide Y stimulates inositol phospholipid hydrolysis in rat brain miniprisms
Neuropeptide Y (NPY) stimulates the hydrolysis of inositol phospholipid in rat brain miniprisms. The stimulation was two-fold in the frontal cortex and in the hippocampus, and 1.5-fold in the… Expand