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Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice.
Currently approved influenza vaccines predominantly protect through antibodies directed against the highly variable glycoprotein hemagglutinin (HA), necessitating annual redesign and formulation… Expand
Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection.
- Hannah C. Watkins, C. Rappazzo, +11 authors D. Putnam
- Biology, Medicine
- Molecular therapy : the journal of the American…
- 5 April 2017
Recombinant, Escherichia coli-derived outer membrane vesicles (rOMVs), which display heterologous protein subunits, have potential as a vaccine adjuvant platform. One drawback to rOMVs is their… Expand