• Publications
  • Influence
Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability.
Human spermatozoa express type-1 cannabinoid receptor (CB1), whose activation by anandamide (AEA) affects motility and acrosome reaction (AR). In this study, we extended the characterization of theExpand
  • 89
  • 6
Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins.
The cellular uptake and the intracellular synthesis/degradation of anandamide are crucial steps for controlling its extracellular level and the duration of its activity. Although the biosynthesis andExpand
  • 108
  • 5
The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease
Activation of cannabinoid receptors (CBs) by endocannabinoids impacts on a number of gastrointestinal functions. Recent data indicate that CB1 agonists improve 2,4-dinitrobenzene sulfonicExpand
  • 58
  • 4
Endocannabinoids Stimulate Human Melanogenesis via Type-1 Cannabinoid Receptor*
Background: Endocannabinoids like anandamide (AEA) play a key role in skin biology. Results: At high concentrations, AEA induces apoptosis of primary human melanocytes through TRPV1 receptors,Expand
  • 40
  • 4
  • PDF
The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models
The effect of the enol carbamate 1-biphenyl-4-ylethenyl piperidine-1-carboxylate (ST4070), a novel reversible inhibitor of fatty acid amide hydrolase (FAAH), was investigated for acute painExpand
  • 51
  • 3
  • PDF
Differences in the Endocannabinoid System of Sperm from Fertile and Infertile Men
Male infertility is a major cause of problems for many couples in conceiving a child. Recently, lifestyle pastimes such as alcohol, tobacco and marijuana have been shown to have further negativeExpand
  • 55
  • 3
  • PDF
p53 and p66 Proteins Compete for Hypoxia-Inducible Factor 1 Alpha Stabilization in Young and Old Rat Hearts Exposed to Intermittent Hypoxia
Background: During development and aging, as well as under hypoxia, many cells can adapt to a stressful environment, while others are damaged and die by apoptosis. In particular, intermittentExpand
  • 40
  • 3
Social encounter with a novel partner in adolescent rats: Activation of the central endocannabinoid system
The endocannabinoid system is critically involved in the modulation of affect, motivation, and emotion. Here, we investigated the hypothesis that changes in the content of endocannabinoid levelsExpand
  • 32
  • 2
Epigenetic control of skin differentiation genes by phytocannabinoids
Endocannabinoid signalling has been shown to have a role in the control of epidermal physiology, whereby anandamide is able to regulate the expression of skin differentiation genes through DNAExpand
  • 40
  • 2
Evidence for the intracellular accumulation of anandamide in adiposomes
Abstract.Anandamide is a lipid messenger that carries out a wide variety of biological functions. It has been suggested that anandamide accumulation involves binding to a saturable cellularExpand
  • 70
  • 1