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Effects of sympathomimetic amines on neuromuscular transmission.
ADRENOTROPIC RECEPTORS IN SKELETAL MUSCLE
Oliver & Schafer (1895) first showed that extracts of the suprarenal medulla increased the tension and prolonged the duration of maximal twitches of the nonfatigued gastrocnemius muscle of the dog.… Expand
Analysis of dose-response curves and calculation of agonist dissociation constants using a weighted nonlinear curve fitting program.
- G. McPherson, P. Molenaar, C. Raper, E. Malta
- Mathematics, Medicine
- Journal of pharmacological methods
- 1 December 1983
The KA value of a full agonist (Furchgott, 1966) is usually calculated following the transformation of a rectangular hyperbolic relationship between equiactive concentrations into a linear… Expand
The in vitro pharmacology of xamoterol (ICI 118,587)
1 The effect of xamoterol and (‐)‐isoprenaline have been compared for their activity at β‐adrenoceptor sites in a number of in vitro cardiac and smooth muscle preparations. 2 Xamoterol produced weak… Expand
Comparison of guinea pig uterine and rat vas deferens preparations for assessment of beta 2-adrenoceptor-mediated activity.
In the present study, investigations were performed to determine the subtype(s) of beta-receptor-mediating relaxation in K+-depolarized guinea pig uterine preparations, and inhibition of twitches in… Expand
Beta-adrenoceptor selectivity of dobutamine: in vivo and in vitro studies.
We compared the beta-adrenoceptor stimulant actions of dobutamine and (-)-isoprenaline in isolated tissue preparations (atria, trachea, and uterus) from the guinea pig and in… Expand
The effects of laboratory handling procedures on naloxone-precipitated withdrawal behavior in morphine-dependent rats.
Previous studies of opiate dependence in our laboratory have shown that opiate-naive (control) animals can display behaviors normally ascribed to withdrawal following naloxone challenge. The… Expand
EFFECTS OF SYMPATHOMIMETIC AMINES ON NEUROMUSCULAR TRANSMISSION
β-Adrenoceptors involved in inhibition of histamine release from sensitized guinea-pig lung
Abstract Selective β-adrenoceptor agonists and antagonists were used to study the type of β-adrenoceptors involved in inhibiting antigen-induced histamine release from actively sensitized guinea-pig… Expand
A comparison between the effects of a tetanus and the effects of sympathomimetic amines on fast- and slow-contracting mammalian muscles.
- W. Bowman, A. Goldberg, C. Raper
- Chemistry, Medicine
- British journal of pharmacology and chemotherapy
- 1 December 1962
The effects of adrenaline and isoprenaline on the tension and time-course of the contractions of the tibialis anterior and soleus muscles of cats and rabbits have been compared with the effects of… Expand