• Publications
  • Influence
Effects of sympathomimetic amines on neuromuscular transmission.
  • W. Bowman, C. Raper
  • Chemistry, Medicine
  • British journal of pharmacology and chemotherapy
  • 1 August 1966
  • 52
  • 2
  • W. Bowman, C. Raper
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1 February 1967
Oliver & Schafer (1895) first showed that extracts of the suprarenal medulla increased the tension and prolonged the duration of maximal twitches of the nonfatigued gastrocnemius muscle of the dog.Expand
  • 86
  • 1
Analysis of dose-response curves and calculation of agonist dissociation constants using a weighted nonlinear curve fitting program.
The KA value of a full agonist (Furchgott, 1966) is usually calculated following the transformation of a rectangular hyperbolic relationship between equiactive concentrations into a linearExpand
  • 44
  • 1
The in vitro pharmacology of xamoterol (ICI 118,587)
1 The effect of xamoterol and (‐)‐isoprenaline have been compared for their activity at β‐adrenoceptor sites in a number of in vitro cardiac and smooth muscle preparations. 2 Xamoterol produced weakExpand
  • 31
  • 1
Comparison of guinea pig uterine and rat vas deferens preparations for assessment of beta 2-adrenoceptor-mediated activity.
In the present study, investigations were performed to determine the subtype(s) of beta-receptor-mediating relaxation in K+-depolarized guinea pig uterine preparations, and inhibition of twitches inExpand
  • 26
  • 1
Beta-adrenoceptor selectivity of dobutamine: in vivo and in vitro studies.
We compared the beta-adrenoceptor stimulant actions of dobutamine and (-)-isoprenaline in isolated tissue preparations (atria, trachea, and uterus) from the guinea pig and inExpand
  • 35
  • 1
The effects of laboratory handling procedures on naloxone-precipitated withdrawal behavior in morphine-dependent rats.
  • T. Pierce, C. Raper
  • Medicine
  • Journal of pharmacological and toxicological…
  • 1 November 1995
Previous studies of opiate dependence in our laboratory have shown that opiate-naive (control) animals can display behaviors normally ascribed to withdrawal following naloxone challenge. TheExpand
  • 14
  • 1
β-Adrenoceptors involved in inhibition of histamine release from sensitized guinea-pig lung
Abstract Selective β-adrenoceptor agonists and antagonists were used to study the type of β-adrenoceptors involved in inhibiting antigen-induced histamine release from actively sensitized guinea-pigExpand
  • 20
A comparison between the effects of a tetanus and the effects of sympathomimetic amines on fast- and slow-contracting mammalian muscles.
The effects of adrenaline and isoprenaline on the tension and time-course of the contractions of the tibialis anterior and soleus muscles of cats and rabbits have been compared with the effects ofExpand
  • 73