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Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Cytokines sing the blues: inflammation and the pathogenesis of depression.
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Current understanding of the mechanisms by which the innate and adaptive immune systems interact with neurotransmitters and neurocircuits to influence the risk for depression are detailed.
A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers.
This proof-of-concept study suggests that TNF antagonism does not have generalized efficacy in treatment-resistant depression but may improve depressive symptoms in patients with high baseline inflammatory biomarkers.
When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders.
Neuroendocrine data provide evidence of insufficient glucocorticoid signaling in stress-related neuropsychiatric disorders, including posttraumatic stress disorder and major depression, which are associated with immune system activation/inflammation, high SNS tone, and CRH hypersecretion.
Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies
To conduct a systematic review and meta‐analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs).
Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress
Effects of mindful-attention and compassion meditation training on amygdala response to emotional stimuli in an ordinary, non-meditative state
- G. Desbordes, L. Negi, T. Pace, B. A. Wallace, C. Raison, E. Schwartz
- PsychologyFrontiers in Human Neuroscience
- 1 November 2012
This study investigated how 8 weeks of training in meditation affects amygdala responses to emotional stimuli in subjects when in a non-meditative state and found a longitudinal decrease in right amygdala activation in the Mindful Attention group in response to positive images, and inresponse to images of all valences overall.
CSF Concentrations of Brain Tryptophan and Kynurenines during Immune Stimulation with IFN-alpha: Relationship to CNS Immune Responses and Depression
Peripheral administration of IFN-α activated IDO in concert with central cytokine responses, resulting in increased brain KYN and QUIN, which correlated with depressive symptoms.
Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior
Identification of mechanisms by which cytokines influence behavior may reveal a panoply of personalized treatment options that target the unique contributions of the immune system to depression.