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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
Selective trafficking of membrane proteins to lysosomes for destruction is required for proper cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins should beExpand
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Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
After endocytosis, some membrane proteins recycle from early endosomes to the plasma membrane whereas others are transported to late endosomes and lysosomes for degradation. Conjugation with theExpand
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Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
The endosomal sorting complexes required for transport (ESCRTs) are required to sort integral membrane proteins into intralumenal vesicles of the multivesicular body (MVB). Mutations in the ESCRT-IIIExpand
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Hrs recruits clathrin to early endosomes
The hepatocyte growth factor‐regulated tyrosine kinase substrate, Hrs, has been implicated in intracellular trafficking and signal transduction. Hrs contains a phosphatidylinositolExpand
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Protein sorting into multivesicular endosomes.
Multivesicular endosomes are important as compartments for receptor downregulation and as intermediates in the formation of secretory lysosomes. Work during the past year has shed light on theExpand
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FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes.
Hrs, an essential tyrosine kinase substrate, has been implicated in intracellular trafficking and signal transduction pathways. The protein contains several distinctive domains, including anExpand
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STAM and Hrs Are Subunits of a Multivalent Ubiquitin-binding Complex on Early Endosomes*
STAM1 and STAM2, which have been identified as regulators of receptor signaling and trafficking, interact directly with Hrs, which mediates the endocytic sorting of ubiquitinated membrane proteins.Expand
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The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4.
Ubiquitination of the chemokine receptor CXCR4 serves as a targeting signal for lysosomal degradation, but the mechanisms mediating ubiquitination and lysosomal sorting remain poorly understood. HereExpand
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Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing
At the onset of metazoan cell division the nuclear envelope breaks down to enable capture of chromosomes by the microtubule-containing spindle apparatus. During anaphase, when chromosomes haveExpand
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Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth
The main organelles of the secretory and endocytic pathways—the endoplasmic reticulum (ER) and endosomes, respectively—are connected through contact sites whose numbers increase as endosomes mature.Expand
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