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Ascorbic acid: a scavenger of superoxide radical.
The second order rate constant for the reaction between ascorbic acid and superoxide at pH 7.4 using the xanthine-xanthine oxidase system was estimated to be 5.4 x 10(6) M-1 sec-1. The results… Expand
Studies on the toxicity of petroleum waxes
1. 1. The experimental approach to the problem of determining the safety of petroleum waxes as incidental additives to human food is discussed. 2. 2. Thirty-six samples of petroleum wax were… Expand
Attempted tumor induction with agaritine in mice.
Agaritine, a constituent of the cultivated mushroom of commerce Agaricus bisporus, was administered at concentrations of 0.0625 and 0.03125% in drinking water daily for life to randomly bred Swiss… Expand
Demonstration of microsomal oxygenation of the benzo ring of 6-nitrobenzo[a]pyrene by thin-layer chromatography.
To explain the biological activity of 6-nitrobenzo[a]pyrene (6-nitroBaP), male Sprague-Dawley rats were induced with 3-methylcholanthrene. Liver microsomes were incubated with magnesium chloride, an… Expand
6-Nitrobenzo[a]pyrene can be denitrated during mammalian metabolism.
- C. Raha, M. Hart-Anstey, M. Cheung, E. Bresnick
- Chemistry, Medicine
- Journal of toxicology and environmental health
Nitropolycyclic aromatic hydrocarbons (nitroarenes), including 6-nitrobenzo[a]pyrene (6-NBap), occur in our environment and are mutagenic in bacterial mutagenesis assays. The mutagenicity of 6-NBaP… Expand
Effect of diet on fecal excretion and gastrointestinal tract distribution of unmetabolized benzo(a)pyrene and 3- methylcholanthrene when these compounds are administered orally to hamsters.
- S. Mirvish, P. Ghadirian, L. Wallcave, C. Raha, S. Bronczyk, J. Sams
- Cancer research
- 1 June 1981
3-Methylcholanthrene (3MC) administered p.o. has induced tumors of the hamster gastrointestinal tract (GIT), including the large intestine. This process may depend on the concentration of unchanged… Expand
Chromatographic and spectral investigations on the in vivo metabolites of 6-nitrobenzo[a]pyrene.
- C. Raha, D. Williamson, P. Thakran, D. Cassada, P. Iversen
- Chemistry, Medicine
- Journal of chromatography
6-Nitrobenzo[a]pyrene (6-NBaP) occurs in the environment, is mutagenic in the Ames assay in the presence of added S9 and is carcinogenic to male but not female mouse liver when injected… Expand
Metabolism of 6-nitrobenzo[a]pyrene in rat lung preparations.
6-Nitrobenzo[alpha]pyrene (6-NBaP) occurs in our environment. Since human exposure to environmental contaminants may occur via the inhalation route, we examined the metabolites of 6-NBaP formed in… Expand
High Pressure Liquid Chromatographic Separation of 6-Acetoxybenzo(A)pyrene from In Vitro Incubation of 6-Nitrobenzo(A)pyrene
Abstract We carried out studies of the microsomal metabolism of 6-nitrobenzo(a)pyrene (NBaP) to understand why the compound is a marginal carcinogen. Microsomal incubation products were separated by… Expand
Covalent binding to protein of the K-region oxide of benzo(a)pyrene formed by microsome incubation.
- C. Raha, C. Gallagher, P. Shubik, S. Peratt
- Biology, Medicine
- Journal of the National Cancer Institute
- 1 July 1976
Incubation of 20,000 X g supernatant proteins of rat liver with benzo]a]pyrene (BP) and appropriate cofactors produced metabolites of BP covalently bound at the 4,5- position to protein. After being… Expand