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Ascorbic acid: a scavenger of superoxide radical.
The second order rate constant for the reaction between ascorbic acid and superoxide at pH 7.4 using the xanthine-xanthine oxidase system was estimated to be 5.4 x 10(6) M-1 sec-1. The resultsExpand
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Studies on the toxicity of petroleum waxes
1. 1. The experimental approach to the problem of determining the safety of petroleum waxes as incidental additives to human food is discussed. 2. 2. Thirty-six samples of petroleum wax wereExpand
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Attempted tumor induction with agaritine in mice.
Agaritine, a constituent of the cultivated mushroom of commerce Agaricus bisporus, was administered at concentrations of 0.0625 and 0.03125% in drinking water daily for life to randomly bred SwissExpand
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Demonstration of microsomal oxygenation of the benzo ring of 6-nitrobenzo[a]pyrene by thin-layer chromatography.
To explain the biological activity of 6-nitrobenzo[a]pyrene (6-nitroBaP), male Sprague-Dawley rats were induced with 3-methylcholanthrene. Liver microsomes were incubated with magnesium chloride, anExpand
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6-Nitrobenzo[a]pyrene can be denitrated during mammalian metabolism.
Nitropolycyclic aromatic hydrocarbons (nitroarenes), including 6-nitrobenzo[a]pyrene (6-NBap), occur in our environment and are mutagenic in bacterial mutagenesis assays. The mutagenicity of 6-NBaPExpand
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Effect of diet on fecal excretion and gastrointestinal tract distribution of unmetabolized benzo(a)pyrene and 3- methylcholanthrene when these compounds are administered orally to hamsters.
3-Methylcholanthrene (3MC) administered p.o. has induced tumors of the hamster gastrointestinal tract (GIT), including the large intestine. This process may depend on the concentration of unchangedExpand
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  • Open Access
Chromatographic and spectral investigations on the in vivo metabolites of 6-nitrobenzo[a]pyrene.
6-Nitrobenzo[a]pyrene (6-NBaP) occurs in the environment, is mutagenic in the Ames assay in the presence of added S9 and is carcinogenic to male but not female mouse liver when injectedExpand
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Metabolism of 6-nitrobenzo[a]pyrene in rat lung preparations.
6-Nitrobenzo[alpha]pyrene (6-NBaP) occurs in our environment. Since human exposure to environmental contaminants may occur via the inhalation route, we examined the metabolites of 6-NBaP formed inExpand
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High Pressure Liquid Chromatographic Separation of 6-Acetoxybenzo(A)pyrene from In Vitro Incubation of 6-Nitrobenzo(A)pyrene
Abstract We carried out studies of the microsomal metabolism of 6-nitrobenzo(a)pyrene (NBaP) to understand why the compound is a marginal carcinogen. Microsomal incubation products were separated byExpand
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Covalent binding to protein of the K-region oxide of benzo(a)pyrene formed by microsome incubation.
Incubation of 20,000 X g supernatant proteins of rat liver with benzo]a]pyrene (BP) and appropriate cofactors produced metabolites of BP covalently bound at the 4,5- position to protein. After beingExpand
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