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Hypertension and chronic ethanol consumption: What do we know after a century of study?
The relationship between ethanol intake and hypertension is reviewed and some mechanisms underlying this response are highlighted, which are of interest for the public health, as ethanol consumption contributes to blood pressure elevation in the population.
Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K+ channels in ETB‐induced relaxation
- C. R. Tirapelli, D. A. Casolari, A. M. de Oliveira
- Biology, MedicineBritish journal of pharmacology
- 1 November 2005
It is firstly demonstrated functionally the existence of both ETA and ETB vasoconstrictor receptors located on the smooth muscle of rat carotid arteries and endothelial ETB receptors that mediated vasorelaxation via NO–cGMP pathway, vasodilator cyclooxygenase product(s) and the activation of voltage‐dependent K+ channels.
Ethanol induces vascular relaxation via redox-sensitive and nitric oxide-dependent pathways.
Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension.
Acute ethanol intake induces superoxide anion generation and mitogen-activated protein kinase phosphorylation in rat aorta: a role for angiotensin type 1 receptor.
Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta.
Hypotensive action of naturally occurring diterpenes: a therapeutic promise for the treatment of hypertension.
Diterpenes: a therapeutic promise for cardiovascular diseases.
- C. R. Tirapelli, S. Ambrósio, F. B. da Costa, A. M. de Oliveira
- ChemistryRecent patents on cardiovascular drug discovery
Diterpenes likely fulfil the definition of a pharmacological preconditioning class of compounds and give hope for the therapeutic use in cardiovascular diseases.
Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle.