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Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3′ to 5′ exonuclease activity essential for immune suppression
Lassa fever virus, a member of the family Arenaviridae, is a highly endemic category A pathogen that causes 300,000–500,000 infections per year in Western Africa. The arenaviral nucleoprotein NP hasExpand
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Ebola Virus VP35 Protein Binds Double-Stranded RNA and Inhibits Alpha/Beta Interferon Production Induced by RIG-I Signaling
ABSTRACT The Ebola virus (EBOV) VP35 protein blocks the virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF-3), a transcription factor critical for the induction ofExpand
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A glutamate switch controls voltage-sensitive phosphatase function
The Ciona intestinalis voltage-sensing phosphatase (Ci-VSP) couples a voltage-sensing domain (VSD) to a lipid phosphatase that is similar to the tumor suppressor PTEN. How the VSD controls enzymeExpand
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Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression
Ebolavirus causes a severe hemorrhagic fever and is divided into five distinct species, of which Reston ebolavirus is uniquely nonpathogenic to humans. Disease caused by ebolavirus is marked by earlyExpand
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Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism
Filoviruses, including Marburg virus (MARV) and Ebola virus (EBOV), cause fatal hemorrhagic fever in humans and non-human primates. All filoviruses encode a unique multi-functional protein termedExpand
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Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses
The innate immune system is one of the first lines of defense against invading pathogens. Pathogens have, in turn, evolved different strategies to counteract these responses. Recent studies haveExpand
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Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
Abstract4-1BB (CD137, TNFRSF9) is an inducible costimulatory receptor expressed on activated T cells. Clinical trials of two agonist antibodies, utomilumab (PF-05082566) and urelumab (BMS-663513),Expand
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Ebola Virus VP 35 Protein Binds Double-Stranded RNA and Inhibits Alpha / Beta Interferon Production Induced by RIGI Signaling
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas; Special PathogensExpand
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Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
4-1BB (CD137, TNFRSF9) is an inducible costimulatory receptor expressed on activated T cells. Clinical trials of two agonist antibodies, utomilumab (PF-05082566) and urelumab (BMS-663513), areExpand
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SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped β-Sandwich Fold Important for SOCE Modulation.
Store-Operated Calcium Entry (SOCE) plays key roles in cell proliferation, muscle contraction, immune responses, and memory formation. The coordinated interactions of a number of proteins from theExpand
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