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Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
Three-dimensional structures of complexes of the SH2 domain of the v-src oncogene product with two phosphotyrosyl peptides have been determined by X-ray crystallography at resolutions of 1.5 and 2.0Expand
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A novel RNA-binding motif in influenza A virus non-structural protein 1
The solution NMR structure of the RNA-binding domain from influenza virus non-structural protein 1 exhibits a novel dimeric six-helical protein fold. Distributions of basic residues and conservedExpand
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Three-dimensional solution structure of the src homology 2 domain of c-abl
SH2 regions are protein motifs capable of binding target protein sequences that contain a phosphotyrosine. The solution structure of the abl SH2 product, a protein of 109 residues and 12.1 kd, hasExpand
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Phase labeling of C−H and C−C spin-system topologies: Application in PFG-HACANH and PFG-HACA(CO)NH triple-resonance experiments for determining backbone resonance assignments in proteins
SummaryTriple-resonance experiments can be designed to provide useful information on spin-system topologies. In this paper we demonstrate optimized proton and carbon versions of PFG-CT-HACANH andExpand
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Phase labeling of C−H and C−C spin-system topologies: Application in constant-time PFG-CBCA(CO)NH experiments for discriminating amino acid spin-system types
SummaryTriple-resonance experiments facilitate the determination of sequence-specific resonance assignments of medium-sized 13C, 15N-enriched proteins. Some triple-resonance experiments can also beExpand
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Sensitivity Enhancement of Triple-Resonance Protein NMR Spectra by Proton Evolution of Multiple-Quantum Coherences Using a Simultaneous 1H and 13C Constant-Time Evolution Period
Short transverse relaxation times of Cα and Hα single-quantum states in proteins reduce signal-to-noise ratios of heteronuclear correlation experiments involving transfers of Cα and Hα coherences. ToExpand
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Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution.
The Src homology 2 (SH2) domain is a recognition motif thought to mediate the association of the cytoplasmic proteins involved in signal transduction by binding to phosphotyrosyl-containing sequencesExpand
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Electrochemical oxidation of enamines related to the key intermediate on thiamin diphosphate dependent enzymic pathways: evidence for one-electron oxidation via a thiazolium cation radical
Electrochemical experiments were performed in Me 2 SO on a number of 2-alkyl and 2-benzylthiazolium ions in the absence and presence of sodium bis(trimethylsilyl) amide (pK=26). Under the latterExpand
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Classification of amino acid spin systems using PFG HCC(CO)NH-TOCSY with constant-time aliphatic 13C frequency labeling
SummaryWe have developed a useful strategy for identifying amino acid spin systems and side-chain carbon resonance assignments in small 15N-, 13C-enriched proteins. Multidimensional constant-timeExpand
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