• Publications
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Strength through structure: visualization and local assessment of the trabecular bone structure
The visualization and subsequent assessment of the inner human bone structures play an important role for better understanding the disease- or drug-induced changes of bone in the context ofExpand
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Automated 3D trabecular bone structure analysis of the proximal femur—prediction of biomechanical strength by CT and DXA
SummaryThe standard diagnostic technique for assessing osteoporosis is dual X-ray absorptiometry (DXA) measuring bone mass parameters. In this study, a combination of DXA and trabecular structureExpand
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Prediction of bone strength by μCT and MDCT-based finite-element-models: how much spatial resolution is needed?
OBJECTIVES Finite-element-models (FEM) are a promising technology to predict bone strength and fracture risk. Usually, the highest spatial resolution technically available is used, but this requiresExpand
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Assessing the biomechanical strength of trabecular bone in vitro using 3D anisotropic nonlinear texture measures: the scaling vector method
We introduce the scaling vector method (SVM): a technique to obtain local non-linear structural information from data sets suitable in cases where anisotropy plays an important role. Expand
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Performance of linear and nonlinear texture measures in 2D and 3D for monitoring architectural changes in osteoporosis using computer-generated models of trabecular bone
We generate models of trabecular bone with pre-defined structural properties which are exposed to simulated osteoclastic activity and analyse their performance with respect to detecting architectural changes. Expand
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Analysis of the topological properties of the proximal femur on a regional scale: evaluation of multi-detector CT-scans for the assessment of biomechanical strength using local Minkowski functionals
We introduce an algorithm that considers the local topological aspects of the bone architecture of the proximal femur allowing to identify regions within the bone that contribute more to the overall mechanical strength than others. Expand
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Advances of 3T MR imaging in visualizing trabecular bone structure of the calcaneus are partially SNR‐independent: Analysis using simulated noise in relation to micro‐CT, 1.5T MRI, and biomechanical
To investigate differences in magnetic resonance imaging (MRI) of trabecular bone at 1.5T and 3.0T and to specifically study noise effects on the visualization and quantification of trabecularExpand
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Application of the Minkowski functionals in 3D to high-resolution MR images of trabecular bone: prediction of the biomechanical strength by nonlinear topological measures
We introduce the Minkowski functionals to medical image processing for the morphological analysis of trabecular bone tissue. Expand
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Quantifying changes in the bone microarchitecture using Minkowski-functionals and scaling vectors: a comparative study
We show that even small changes in the trabecular structures, which are induced by variation of a control parameter of the system, become discernible by applying both the MF and the locally adapted scaling vector method. Expand
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The 3D-based scaling index algorithm to optimize structure analysis of trabecular bone in postmenopausal women with and without osteoporotic spine fractures
The scaling index method (SIM) is a recently proposed non-linear technique to extract texture measures for the quantitative characterisation of the trabecular bone structure in high resolution magnetic resonance imaging (HR-MRI). Expand
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