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Quantification for the importance degree of engineering characteristics with a multi-level hierarchical structure in QFD
Quantification for the importance degree of engineering characteristics (ECs) is an essential problem in quality function deployment. In real-world scenario, it is sometimes difficult to directlyExpand
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Ubiquitin-specific protease 4 promotes metastasis of hepatocellular carcinoma by increasing TGF-β signaling-induced epithelial-mesenchymal transition
Invasion and metastasis are the main cause of recurrence and death in advanced hepatocellular carcinoma (HCC). Revealing the mechanisms of HCC metastasis is important for developing new therapeuticExpand
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Cholesterol impairs hepatocyte lysosomal function causing M1 polarization of macrophages via exosomal miR-122-5p.
Nonalcoholic steatohepatitis (NASH) is a major threat to health worldwide. Lipotoxicity and macrophage-mediated inflammation play key roles in the pathogenesis of NASH. In this study, we found thatExpand
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Protocadherin-10 acts as a tumor suppressor gene, and is frequently downregulated by promoter methylation in pancreatic cancer cells.
Protocadherin-10 (PCDH10), a member of non-clustered protocadherin family which plays important roles in calcium-dependent cell-cell signal transduction and adhesion. PCDH10 functions as a tumorExpand
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Cholesterol attenuated the progression of DEN-induced hepatocellular carcinoma via inhibiting SCAP mediated fatty acid de novo synthesis.
  • Z. Zhao, L. Zhong, +4 authors J. Gong
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 19 February 2019
Worldwide, hepatocellular carcinoma (HCC) remains a top instigator of cancer mortality. Previous clinical studies have revealed that low serum cholesterol predicts a poor outcome in HCC patients, butExpand
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Inhibition of DACH1 activity by short hairpin RNA represses cell proliferation and tumor invasion in pancreatic cancer.
Cancer of the pancreas is one of the most lethal diseases worldwide. Better understanding of the molecular mechanisms involved in tumorigenesis is of great consequence to elevate the survival rate.Expand
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Hybrid reliability analysis with uncertain statistical variables, sparse variables and interval variables
ABSTRACT There are differences among sampling data and representation types of uncertain statistical variables, sparse variables and interval variables, which increase the complexity of structureExpand
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Isogeometric analysis of large thin shell structures based on weak coupling of substructures with unstructured T-splines patches
TLDR
A new isogeometric analysis method is proposed for large thin shell structures based on the weak coupling of substructures with unstructured T-splines patches. Expand
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A novel support vector regression algorithm incorporated with prior knowledge and error compensation for small datasets
TLDR
We propose a nested support vector regression model, which incorporates prior knowledge into $$\nu $$ν-LPSVR, compensates for the errors between prior knowledge data and the measured data, and achieves small training error for both the prediction model and the error compensation model. Expand
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Simulation-based robust design of complex product considering uncertainties of metamodel, design variables, and noise parameters
The uncertainties of design variables, noise parameters, and metamodel are important factors in simulation-based robust design optimization. Most conventional metamodel construction methods onlyExpand
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