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Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel.
Osteopontin is a phosphorylated bone matrix sialoprotein, postulated to play a regulatory role in biomineralization. The effects of a crude preparation of rat bone osteopontin and a more highlyExpand
Validation of Peripheral Dual‐Energy X‐Ray Absorptiometry for the Measurement of Bone Mineral in Intact and Excised Long Bones of Rats *
  • T. Nagy, C. Prince, J. Li
  • Chemistry, Medicine
  • Journal of bone and mineral research : the…
  • 1 September 2001
We evaluated the precision and accuracy of peripheral dual‐energy X‐ray absorptiometry (DXA) for the measurement of bone mineral density (BMD) and bone mineral content (BMC) in intact and excisedExpand
1,25-Dihydroxyvitamin D3 regulates the biosynthesis of osteopontin, a bone-derived cell attachment protein, in clonal osteoblast-like osteosarcoma cells.
We investigated the effects of 1,25-dihydroxyvitamin D3 on the synthesis of osteopontin, a phosphorylated cell attachment glycoprotein, in ROS 17/2.8 cells, a clonal osteoblast-like rat osteosarcomaExpand
Osteopontin, a substrate for transglutaminase and factor XIII activity.
Osteopontin (OPN), an extracellular matrix cell adhesion protein, was found to serve as a substrate for the incorporation of radiolabelled putrescine mediated by a commercial preparation of guineaExpand
Isolation and partial characterization of proteoglycans from rat incisors.
Newly synthesized proteoglycans of rat incisors were labelled in vivo for 6h with [35S]-sulphate in order to facilitate their detection during purification and characterization. Proteoglycans wereExpand
Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor.
Type beta transforming growth factor (TGF beta) was shown to regulate the production of several extracellular matrix proteins. Osteopontin (OP) is a recently discovered bone matrix protein which wasExpand
Cyclic GMP-dependent protein kinase inhibits osteopontin and thrombospondin production in rat aortic smooth muscle cells.
Vascular lesions resulting from injury are characterized by a thickening of the intima brought about in part through the production of increased amounts of extracellular matrix proteins by theExpand
Isolation, characterization, and biosynthesis of a phosphorylated glycoprotein from rat bone.
A phosphorylated glycoprotein was purified from the mixture of proteins extracted by demineralization of rat bone with 0.5 M EDTA in 4 M guanidinium chloride. A high level of purity for theExpand
Immunohistochemical demonstration of a 44-KD phosphoprotein in developing rat bones.
Polyclonal antibodies against a 44-KD phosphoprotein (44K BPP) from rat bone were raised in rabbits, affinity-purified, and used as probes to study the protein's distribution in various types ofExpand
Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts.
OBJECTIVE Osteopontin (OPN) is an extracellular matrix protein that has been implicated in the interactions between tumor cells and host matrix, including those involved in invasion and spread ofExpand
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