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Causal relationship between stressful life events and the onset of major depression.
OBJECTIVE Stressful life events are associated with the onset of episodes of major depression. However, exposure to stressful life events is influenced by genetic factors, and these factors areExpand
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The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women.
BACKGROUND Patterns of comorbidity suggest that the common psychiatric and substance use syndromes may be divisible into 2 broad groups of internalizing and externalizing disorders. We do not knowExpand
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Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis.
BACKGROUND Women who report childhood sexual abuse (CSA) are at increased risk for developing psychiatric disorders in adulthood. What is the diagnostic specificity and cause of this association? Expand
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Dimensions of religiosity and their relationship to lifetime psychiatric and substance use disorders.
OBJECTIVE The role of religion in mental illness remains understudied. Most prior investigations of this relationship have used measures of religiosity that do not reflect its complexity and/or haveExpand
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The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication.
CONTEXT Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified? Expand
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The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression.
OBJECTIVE Three potent risk factors for major depression are female sex, the personality trait of neuroticism, and adversity resulting from exposure to stressful life events. Little is known aboutExpand
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A population-based twin study of the relationship between neuroticism and internalizing disorders.
OBJECTIVE The anxiety and depressive disorders exhibit high levels of lifetime comorbidity with one another. The authors examined how genetic and environmental factors shared by the personality traitExpand
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Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins.
OBJECTIVE Data on use and misuse of six classes of illicit substances by male twin pairs were used to examine whether genetic and shared environmental risk factors for substance use disorders areExpand
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Toward a comprehensive developmental model for major depression in women.
OBJECTIVE: Major depression is a multifactorial disorder with many etiologic variables that are interrelated through developmental pathways. The authors used structural equation modeling to generateExpand
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A population-based twin study in women of smoking initiation and nicotine dependence.
BACKGROUND The development of drug dependence requires prior initiation. What is the relationship between the risk factors for initiation and dependence? METHODS Using smoking as a model addiction,Expand
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