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The transcriptional repressor Snail promotes mammary tumor recurrence.
Breast cancer recurrence is a fundamental clinical manifestation of tumor progression and represents the principal cause of death from this disease. Using a conditional transgenic mouse model for theExpand
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Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat.
Conjugated linoleic acid (CLA) is a naturally occurring fatty acid which has anti-carcinogenic and anti-atherogenic properties. CLA activates PPAR alpha in liver, and shares functional similaritiesExpand
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Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression.
Conjugated linoleic acid (CLA) isomers have a number of beneficial health effects, as shown in biomedical studies with animal models. Previously, we reported that a mixture of CLA isomers improvedExpand
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Leptin is present in human milk and is related to maternal plasma leptin concentration and adiposity.
Leptin is elevated during pregnancy and may be involved in the regulation of milk production in women. Immunoreactive leptin was quantified in human milk by modified radioimmunoassay. LeptinExpand
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Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.
The metabolic demands and synthetic capacity of the lactating mammary gland exceed that of any other tissue, thereby providing a useful paradigm for understanding the developmental regulation ofExpand
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Growth hormone regulates leptin gene expression in bovine adipose tissue: correlation with adipose IGF-1 expression.
Leptin, the product of the ob gene, is secreted from white adipocytes and regulates food intake and whole-body energy metabolism. In rodents and humans, leptin gene expression is under complexExpand
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Expression and cDNA cloning of porcine peroxisome proliferator-activated receptor gamma (PPARgamma).
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the PPAR subfamily of nuclear hormone receptors. In rodents and humans, expression of PPARgamma is predominantly found inExpand
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Leptin and its receptors: regulators of whole-body energy homeostasis.
Leptin is the adipocyte-specific product of the ob gene. Expression of leptin in fully fed animals reflects adipocyte size and body-fat mass. Leptin signals the status of body energy stores to theExpand
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Akt is required for Stat5 activation and mammary differentiation
IntroductionThe Akt pathway plays a central role in regulating cell survival, proliferation and metabolism, and is one of the most commonly activated pathways in human cancer. A role for Akt inExpand
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T-bet Is Required for the Rapid Clearance of Attenuated Rabies Virus from Central Nervous System Tissue
Much of our understanding of CNS immunity has been gained from models involving pathological inflammation. Attenuated rabies viruses (RABV) are unique tools to study CNS immunity in the absence ofExpand
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