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Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay.
There is a concern that chemicals in our environment are affecting human health by disrupting normal endocrine function. Much of the concern has focused on chemicals that can interact directly withExpand
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Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples.
Statistical tests of carcinogenicity are shown to have varying degrees of robustness to the effects of mortality. Mortality induced by two different mechanisms is studied--mortality due to the tumorExpand
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Temperature, air pollution, and hospitalization for cardiovascular diseases among elderly people in Denver.
Daily measures of maximum temperature, particulate matter less than or equal to 10 micro m in aerodynamic diameter (PM10), and gaseous pollution (ozone, nitrogen dioxide, sulfur dioxide, and carbonExpand
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Human exposure estimates for phthalates.
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Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis
Background: A recent review by the International Agency for Research on Cancer (IARC) updated the assessments of the > 100 agents classified as Group 1, carcinogenic to humans (IARC Monographs VolumeExpand
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A human health perspective on climate change: a report outlining the research needs on the human health effects of climate change
EHP is an open-access monthly journal of peer-reviewed research and news on the impact of the environment on human health. EHP also publishes a quarterly Chinese Edition (ISSN 1542-6351) andExpand
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Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening
Background The propensity of compounds to produce adverse health effects in humans is generally evaluated using animal-based test methods. Such methods can be relatively expensive, low-throughput,Expand
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Characterization of the dose-response of CYP1B1, CYP1A1, and CYP1A2 in the liver of female Sprague-Dawley rats following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
One of the current knowledge gaps in the evaluation of risk for human exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the relationship between gene expression induced by TCDDmore complexExpand
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Dose-Additive Carcinogenicity of a Defined Mixture of “Dioxin-like Compounds”
Use of the dioxin toxic equivalency factor (TEF) approach in human risk assessments assumes that the combined effects of dioxin-like compounds in a mixture can be predicted based on aExpand
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Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis.
Nongenotoxic carcinogens are chemicals that induce neoplasia without it or its metabolites reacting directly with DNA. Chemicals classified as nongenotoxic carcinogens have been assumed to act asExpand
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