• Publications
  • Influence
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
The mechanisms by which lipids and lipidic excipients affect the oral absorption of lipophilic drugs are detailed and a perspective on the possible future applications of lipid-based delivery systems is provided.
Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies.
  • C. Pouton, C. Porter
  • Computer Science, Medicine
    Advanced drug delivery reviews
  • 17 March 2008
The properties of excipients are discussed, the formulation strategies that can be used for each type of lipid formulation are outlined, and a framework for the in vitro testing of each type is suggested.
Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH.
Case studies are presented in which postprandial changes in bioavailability are rationalized in terms of the sensitivity of the physicochemical properties of the administered drug to the altered GI environment.
Strategies to Address Low Drug Solubility in Discovery and Development
The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Enhancing intestinal drug solubilisation using lipid-based delivery systems.
The mechanistic rationale which underpins the use of lipid-based delivery systems to enhance drug solubilisation is described and the available literature describing increases in oral bioavailability after the administration of lipid solution, suspension and self-emulsifying formulations is reviewed.
Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility
The fundamental principles that underpin drug precipitation mechanisms are presented, the mechanisms by which precipitation may be inhibited are described, the methods that can be used to identify polymeric precipitation inhibitors (PPIs), and current literature evidence of the most effective PPIs are summarized.
Lymphatic transport of proteins after subcutaneous administration.
This mini-review summarizes the relevant literature regarding the lymphatic transport of proteins after subcutaneous administration and highlights the importance of lymphatic uptake and transport in understanding the biopharmaceutical properties of protein drugs and potentially targeting the lymphatics.
From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control, and the varying mechanisms of lymphatic entry and transport are summarized, as well as discussing examples ofymphatic delivery that have enhanced therapeutic utility.
Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine
Abstract The potential for lipidic self-emulsifying drug delivery systems (SEDDS) and self-microemulsifying drug delivery systems (SMEDDS) to improve the oral bioavailability of a poorly absorbed,
Intestinal lymphatic drug transport: an update.
The mechanism of access of drugs to the intestinal lymph and the role of lipid digestion and absorption in the stimulation of lymphatic transport, and the ability of different lipid types to stimulate lymphatic drug transport, are addressed.