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CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance.
TLDR
CD117 and Stro-1 identify osteosarcoma TICs associated with the most lethal characteristics of the disease-metastasis and drug resistance-and these markers offer candidates for TIC-targeted drug delivery aimed at eradicating osteosARcoma. Expand
Iron deficiency and in vitro iron chelation reduce the expression of cluster of differentiation molecule (CD)28 but not CD3 receptors on murine thymocytes and spleen cells
TLDR
Data suggest that altered CD28 expression may contribute to reduced T-cell proliferation during Fe deficiency, and indicates that reduced CD3 andCD28 expression is one of them. Expand
Chronic Δ-9-tetrahydrocannabinol Administration Increases Lymphocyte CXCR4 Expression in Rhesus Macaques
TLDR
Results show that chronic THC administration produces changes in T cell phenotype, which can potentially contribute to host immunomodulation to infectious challenges. Expand
Dynamics of ADAM17-Mediated Shedding of ACE2 Applied to Pancreatic Islets of Male db/db Mice
TLDR
It is concluded that whereas ADAM 17 has the ability to shed ACE2, ADAM17 does not deplete ACE2 from pancreatic islets in diabetic db/db mice. Expand
CD 117 and Stro-1 Identify Osteosarcoma Tumor-Initiating Cells Associated with Metastasis and Drug Resistance
Authors' 3Patholog University Tulane Uni Note: Sup Research O Correspon Louisiana S CSRB Roo 504-568-85
The major CD8 T cell effector memory subset in the normal and Chlamydia trachomatis-infected human endocervix is low in perforin
TLDR
The low perforin content of CD8 TEM cells in the endocervix, the local site of C. trachomatis infection in women, may reflect the unique immunological environment that balances immune protection against sexually transmitted infections and immune- tolerance to support conception. Expand
Neurocytometry: Flow Cytometric Sorting of Specific Neuronal Populations from Human and Rodent Brain.
TLDR
The neurocytometry methodology described here has the potential to significantly expand studies to analyze the effects of drugs, environmental manipulations, and disease states on the nucleic acid and protein content of specific brain cell populations. Expand
Reduced thymocyte proliferation but not increased apoptosis as a possible cause of thymus atrophy in iron-deficient mice
TLDR
Results suggest that reduced cell proliferation but not increased apoptosis is the cause of thymus atrophy associated with iron deficiency. Expand
Alcohol Impairs the Myeloid Proliferative Response to Bacteremia in Mice by Inhibiting the Stem Cell Antigen-1/ERK Pathway
TLDR
Data indicate that Sca-1 expression promotes ERK-dependent myeloid cell proliferation during bacteremia, which could represent an underlying mechanism for developing myelosuppression in alcohol-abusing hosts with severe bacterial infection. Expand
Chronic alcohol increases CD8+ T-cell immunosenescence in simian immunodeficiency virus-infected rhesus macaques.
TLDR
The results suggest that CBA and AUD augment immune activation and immunosenescence in SIV-infected macaques and PLWHA. Expand
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