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Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells.
TLDR
It is concluded that hypoxia induced a downregulation of expression and activity of epithelial Na channels and Na,K-ATPase in alveolar cells and this was associated with complete functional recovery. Expand
Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo.
TLDR
Findings suggest that release of VEGF synthesized by AEC may target not only endothelial cells but also other alveolar cells, including macrophages and epithelial cells, as well as bronchoalveolar lavage fluid. Expand
Regulation of the epithelial Na+ channel by peptidases.
TLDR
Several converging lines of evidence indicate that ENaC function is regulated by peptidases, and that such regulation is critical for embryonic development and adult function of organs such as skin, kidney, and lung. Expand
Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells.
TLDR
It is established that hypoxia-induced inhibition of amiloride-sensitive sodium channel activity is mediated by decreased apical expression of ENaC subunits and that beta(2)-agonists reverse this effect by enhancing the insertion of ENc subunits into the membrane of hypoxic alveolar epithelial cells. Expand
Defective ENaC Processing and Function in Tissue Kallikrein-deficient Mice*
TLDR
It is demonstrated that TK, like several other proteases, can activate ENaC in the kidney and the colon, and was able to promote γ-ENaC cleavage in vitro. Expand
Inhibition of Na-K-ATPase activity after prolonged hypoxia in an alveolar epithelial cell line.
TLDR
It is indicated that prolonged hypoxic exposure impairs Na-K-ATPase activity in SV40 ATII cells and may therefore decrease the vectorial sodium transport by alveolar epithelium. Expand
Gene regulation in the adaptive process to hypoxia in lung epithelial cells.
TLDR
This review focuses on the role of HIF isoforms expressed in alveolar epithelial cells exposed to hypoxia and on the specific hypoxic gene regulation that takes place in alvesolar epithelium either through HIF-dependent or -independent pathways. Expand
Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury.
TLDR
Results indicate that MSC-M may be a preferable therapeutic option for ALI, and suggest a possible role for KGF in the beneficial effect of M SCs. Expand
Importance of ENaC-Mediated Sodium Transport in Alveolar Fluid Clearance Using Genetically-Engineered Mice
TLDR
The role of ENaC in alveolar lung liquid clearance is focused on and recent data from mouse models with altered activity of epithelial sodium channel function in the lung are discussed, illustrating the impaired lung fluid clearance in these adult mice. Expand
Hypoxia and β2-Agonists Regulate Cell Surface Expression of the Epithelial Sodium Channel in Native Alveolar Epithelial Cells*
TLDR
It is established that hypoxia-induced inhibition of amiloride-sensitive sodium channel activity is mediated by decreased apical expression of ENaC subunits and that β2-agonists reverse this effect by enhancing the insertion of ENc subunits into the membrane of hypoxic alveolar epithelial cells. Expand
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