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Meta‐analysis of the influence of I148M variant of patatin‐like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
Examining the strength of the effect of the I148M (rs738409 C/G) patatin‐like phospholipase domain containing 3 (PNPLA3) variant on nonalcoholic fatty liver (NAFLD) and disease severity across different populations provided unequivocal evidence of rs738 409 as a strong modifier of the natural history of NAFLD in different populations around the world.
Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis
In vitro exploration showed that overexpression of miR-122 enhances alanine aminotransferase activity, and NAFLD has a distinguishing circulating miRNA profile associated with a global dysmetabolic disease state and cardiovascular risk.
A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
- S. Sookoian, G. Castaño, A. Burgueño, T. Gianotti, María Soledad Rosselli, C. Pirola
- Biology, MedicineJournal of Lipid Research
- 1 October 2009
The data suggest that the rs738409 G allele is associated not only with fat accumulation in the liver but also with liver injury, possibly triggered by lipotoxicity.
Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review.
Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease
Hematic methylation and transcriptional activity of the MT-ND6 are associated with the histological severity of NAFLD, and Ultrastructural evaluation showed that NASH is associated with mitochondrial defects and peroxisome proliferation.
Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator–activated receptor γ coactivator 1α promoter
The data suggest that the IR phenotype and the liver transcriptional activity of PPARGC1A show a tight interaction, probably through epigenetic modifications.
Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity
We explored the role of transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 C/T nonsynonymous (p.Glu167Lys) variant in genetic susceptibility to nonalcoholic fatty liver disease (NAFLD) and…
Effects of rotating shift work on biomarkers of metabolic syndrome and inflammation
The effect of rotating shift work schedule on leucocyte count and its relationship with risk factors of metabolic syndrome (MS) are explored.
Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition.
The UGT1A1 Gilbert syndrome variant rs6742078 is associated with gallstone disease in men; further studies are required regarding the sex-specific physiology of bilirubin and bile acid metabolism.
Systematic review with meta‐analysis: risk factors for non‐alcoholic fatty liver disease suggest a shared altered metabolic and cardiovascular profile between lean and obese patients
The pathogenesis of non‐alcoholic fatty liver disease (NAFLD) is closely associated with the co‐occurrence of multiple pathological conditions characterising the metabolic syndrome (MetS), obesity in…