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Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A2 from Bothrops pirajai venom
TLDR
Harpalycin 2 changes the structure of PrTX-III, inhibiting the enzymatic activity of this enzyme, and can be valuable tools for searching new anti-phospholipase A2 drugs. Expand
Evaluation of Macroalgae Sulfated Polysaccharides on the Leishmania (L.) amazonensis Promastigote
TLDR
The assayed sulfated polysaccharides were able to modulate the growth rate and cell survival of Leishmania (L.) amazonensis promastigotes in in vitro assays, and these effects involved the interaction of the sulfatedpolysaccharide on the cell membrane of the parasites. Expand
Genotoxicity induced by nerol, an essential oil present in citric plants using human peripheral blood mononuclear cells (PBMC) and HepG2/C3A cells as a model
TLDR
Both cell types exhibited significant DNA damage and chromosomal mutations after medium and high concentration incubation with nerol indicating that the safety of use of this monoterpene in various formulations to which humans are exposed needs to be monitored and requires more comprehensive investigations. Expand
Sulfated polysaccharide extracted of the green algae Caulerpa racemosa increase the enzymatic activity and paw edema induced by sPLA2 from Crotalus durissus terrificus venom
TLDR
A pharmacological assay showed that the myotoxic activity of s PLA2:CrSP is unrelated to its enzymatic activity and that sPLA2: CrSP may have a practical application as a natural antibacterial agent for use in humans and commercially raised animals. Expand